The Media Misrepresents Tim Buie on Dietary Intervention in Autism

Today there is a slew of stories in the media about a study by headed by Tim Buie of Harvard that claim that dietary interventions doesn't work for autism.

Except that I sat through Dr. Buie's lecture at the Maine CDC Autism conference last year while he talked about how dietary interventions do work for some with autism.

He emphasized that at least 30% of those with autism have GI issues, the GFCF diet was NOT appropriate for all people with autism, but was for some, that the SCD diet showed good promise for a small subset of those with autism, and that the principles of the Fiengold diet should be adopted by the society as a whole.

He belives that dietary intervention is appropriate in people with autism who are showing food sensitivities. But you wouldn't know that by reading the media reports.

So instead of taking the biased media's word for it, take an hour and find out what Dr. Buie really thinks about dietary intervention in autism:

Maine CDC Autism Conference 2009
Gastrointestinal and Nutritional Co-Morbidities in Autism, followed by Q&A
Tim Buie, MD
Pediatric Gastroenterologist
LADDERS Program, MassGeneral Hospital for Children
Harvard Medical School



Questions from the Audience



I strongly encourage you to also watch the two lectures that followed Dr. Buie's at the Maine CDC Conference:

Dr. Martha Herbert's lecture on the gene environment interaction in autism
and
Dr. Jon Poling's lecture on vaccines and autism.

Maine CDC Autism Conference: Gastrointestinal and Nutritional Co-Morbidities in Autism by Tim Buie, MD

Maine CDC Autism Conference 2009
Gastrointestinal and Nutritional Co-Morbidities in Autism, followed by Q&A
Tim Buie, MD
Pediatric Gastroenterologist
LADDERS Program, MassGeneral Hospital for Children
Harvard Medical School



Questions from the Audience



Next Session:
Kim Block from WGME presents news piece on Autism treatment.

SCDBakery.com for Thanksgiving

So last month we ordered some Halloween yummies for Chandler through the SCD Bakery, and my very picky eater baby gobbled them all up.

So for those of you who want to get some Thanksgiving yums for your little GFCF/SDC chickens, I highly recommend Jill's particular yums.

This was her email this week. Her menu rotates every week, you have to order for Thanksgiving by Nov. 13:

SCD Bakery
Dear Ginger,

Baking for Thanksgiving:
Apple Delight
Blueberry Delight
Pumpkin Bread
Pecan Apple Muffins
Banana Whoopie Pies
Apple Cinnamon Whoopie Pies

NOTE: The baking schedule for Thanksgiving will be a little different than usual with orders due Thursday Nov. 13th instead of Sunday and shipped to the West Coast on Monday Nov. 17th and the East Coast on Thursday Nov 20th to ensure delivery in time for the holiday. All menu items can be frozen.

Please note orders will close on Thursday at midnight, due to time limitations we will not be able to accept any orders placed after Thursday. :)
Orders due by Thursday November 13th.

WISHING EVERYONE A HAPPY THANKSGIVING !

Take Care,

Jill Rainville
SCD Bakery

Monsanto GMOs: My Questions about Monsanto’s GMOs and Autism

Watching The World According to Monsanto, I was struck by the section of the film about Árpád Pusztai’s research that showed that rats fed GMO potatoes developed gut problems and an immune response. The section is as follows:

Árpád Pusztai, world renowned scientist lost his job when he warned about GE (genetically engineered or genetically modified) foods.

1998 Aberdeen, Scotland

Árpád Pusztai worked for the Rowett Institute in Scotland. At the Ministry of Agriculture’s request, he lead a study on genetically modified potatoes with a budget of over two million Euros and a staff of 30 researchers, to prepare the arrival of GMOs in Great Britain.

"We were all enthusiastic about it… I was enthusiastic about it… The ministry thought that if we did this study, looking at all aspects, then it would be an endorsement of GM and when they introduce it, they will say that the foremost laboratory in Europe… nutritional laboratory… had looked at them and found them all right."

Árpád Pusztai specializes in lectins, these proteins function as an insecticide protecting plants against aphids. Rowett scientists had created potatoes that were resistant to aphids, and into which they introduced a snowdrop gene which produces the lectin in question. Beforehand they verified that in their naturally occurring state, lectins themselves do not pose a health risk.

The genetically modified potatoes were tested on rats.

"It had a twofold effect. First it started to increase a proliferative response in the gut… and that you don’t like… because this is possibly… I am not saying it is cancerous… but what it does… it can have an adjuvant effect on any chemical… any chemically induced tumor.

The other thing is that the immune system was certainly… got into high gear. And that was… we don’t know whether that is good or bad. But it certainly did recognize the GM potatoes as alien. And we were convinced that this insertion is causing the problem and not the trans gene. As I said, the trans gene when we did it in isolation, even at 800 fold concentration, didn’t do any harm.

It was a very important point because the American FDA is going on by mutual Technology. And what we did say and what we did publish actually corroborated and confirmed that it was not the trans gene that was the problem, but it was the technology."

When Pusztai was interviewed by the BBC, with permission from his bosses, he stated:

"As a scientist actively working on the field, I find that it is very, very unfair to use our fellow citizens as guinea pigs."

The day after the statement was broadcast, Pusztai was fired and the team was dismantled.

While watching this, I put together a few things:

1. Dr. Pusztai’s finding, that GM potatoes triggered gut problems and an immune response.
2. The additional section of the documentary which discussed the migration of trans genes (genes that have been genetically modified and inserted into cells that then become a part of the DNA) from GM corn sold in the US to native corn grown in rural southern Mexico.
3. A comment that David Kirby made in his column that reported on the March 11th CDC conference call that discussed the Hanna Poling mitochondrial disorder and its link to autism.

Kirby wrote:

"Some researchers believe that the modern American diet is largely to blame for an increase in the number of children whose underlying mitochondrial dysfunction is "triggered" into autism by febrile infections.

The answer, they hypothesize, is corn.

The American diet has become extraordinarily dependent on corn oil and corn syrup used in processing, these experts contend. They say that corn oil and syrup are inflammatory, whereas fish oil is anti-inflammatory. Could our diet be a factor in making this mutated gene become more pathogenic?"

In an email conversation with Mr. Kirby while he was researching that conference call, he wrote to me that:

"One of the top scientists I spoke with today said the increase in autism in America was due to consumption of corn"

His comments in the article about the theoretical corn/inflammation link to autism were straight from a high level scientist involved with the CDC and on that conference call.

Putting all these together, my questions are these:

||Could not just over exposure to corn be the problem, but exposure to genetically modified corn, presumably that used the same problematic technology as Dr. Pusztai’s believed was to blame for the gut inflammation and immune response in his rats that were eating genetically modified potatoes?||

||And what exactly does the CDC believe to be the relationship between the American diet, overconsumption of corn products, inflammation and autism?||

||And if they believe, or even suspect, that inflammation is at play in the bodies of children with autism, why have they not stated this publicly and encouraged research and treatment along these lines?||

||And if they believe there might be a link, then why are they not investigating and promoting the Specific Carbohydrate Diet that removes corn products?||

Most vaccine induced regressions happen after a child's first birthday, around 18 months to age two, after they have begun eating processed foods; and we have no way of knowing if those were GMO foods unless we only bought foods that were labeled organic.

||Was there an inflammatory/autoimmune response already going on in our children, due to the gm foods they were consuming, that set them up for vaccine injuries because they had taken in one adjuvant too many?||

Remember Dr. Pusztai's words, "it can have an adjuvant effect on any chemical"

The standard contraindication for vaccination is the illness of the child because their immune system is not properly regulated to safely accept the vaccine. Parents are taught not to vaccinate when their child has a cold or the flu or any other viral illness. But if our kids had dis regulated immune systems at the time of vaccination due to GM food derived immune system over stimulation, we would have no way of knowing, and would be presumably be putting our kids at risk for further immune system damage by vaccinating at a time of immune activation.

Corn is a problem for many of our kids. Because genetically modified food products are not labeled, we have no way of figuring out if our kids are having problems with corn, or GM corn. Or if one causes a bigger problem than the other. In fact we have no way of knowing at all what GM foods might be doing to our children.

Chandler drank milk by the truck load before he regressed, it was probably Bovine Growth Hormone milk, which is found to have inflammatory effects on the cows and because of the illness of the cows puss is in the milk, as well as the antibiotics that were given to the cows to counter the infections. To say nothing of the hormone itself which also may be in the milk.

||So is the very good response that my own son had to the GFCF/SCD Diet, which removes grains, dairy and processed foods, and encourages eating only organic foods, due in part to the fact that he is no longer eating pro-inflammatory genetically modified foods?||

The way most of the interventions that help our kids are discovered are by happy accidents, we find something that helps them, then spend 5 years trying to figure out exactly why it works for them.

||What if the SCD diet worked not just because it was removing complex carbohydrates that feed yeast, but also because it was removing foods that were having an adjuvant effect on him?||

His belly went from puffy (suggesting gut inflammation) to flat in about three weeks.

There has not been any discussion that I know of surrounding the potential role of GM foods and autism in our community. I am assuming because, like me, none of us knew our kids were eating them. It is certainly an important discussion to be had as many of our kids on GFCF diets will continue to eat processed foods with genetically modified ingredients. The most immediate treatment question that jumps to mind is:

||Are poor responders to the GFCF diet still getting so many processed GM foods that gut inflammation and autoimmune responses remains high and negates much of the good the diet may do them?||

But bottom line for me, the biggest question I have is:

||WHAT THE HELL HAVE I BEEN FEEDING MY CHILDREN FOR THE LAST SEVEN YEARS???||

UPDATE:

I TOTALLY FORGOT ABOUT PESTICIDES AND HERBICIDES!

These plants are being engineered so that they can be doused in Roundup herbicide and so that they produce their own pesticides, and we already have evidence that bug and weed killers are implicated in autism and mitochondrial disorders, which HHS and Julie Gerberding herself say are at play in vaccine injuries that produce autism 'symptoms'.

Hidden Dangers in Kids' Meals 28min

The Wakefield Witch-Hunt

The Wakefield witch-hunt
Friday, 21st March 2008
The Spectator

A couple of days ago, yet another story appeared claiming that fresh research had shown that there was no link between the MMR vaccination and autism. This new research was said to have shown that, contrary to the claims made by Dr Andrew Wakefield, the surgeon at the centre of the MMR scare, there was no relationship between gut problems and autism, the core of his concerns. It also claimed that the discovery furthermore damaged the related theory that a gluten-free diet could help children with autism.

Dr Hilary Cass, from Great Ormond Street, said: ‘It is very distressing to have a diagnosis of autism, a lifelong condition.Many families are driven to try out interventions which currently have no scientific basis. For example, advocates of the leaky gut hypothesis offer children a casein and gluten-free diet which as yet lacks an evidence base.’

This particular observation is a telling indication that this study bears little relation to reality. For there are countless families whose autistic children’s suffering from gut problems has only been eased, and their autistic symptoms improved, by the introduction of precisely such a diet. ‘No evidence base’? Tell that to those families. It is their lived experience.

Second, despite the way this was presented in the media this is not a new piece of research at all. It is instead a recycled version of a study by Baird G. et al, published in the Archive of Diseases in Childhood on February 5 and reported in the press around that time. The study drew the following response from Andrew Wakefield:

…The study is severely limited by case definition in the context of the crucial ‘possible enterocolitis’ group. For inclusion in this group they required the presence of two or more of the following five current gastrointestinal symptoms:

* current persistent diarrhea (defined as watery/loose stools three or more times per day >14 days),
* current persistent vomiting (occurring at least once per day, or more than five times per week),
* current weight loss,
* current persistent abdominal pain (3 or more episodes [frequency not specified by authors] severe enough to interfere with activity);
* current blood in stool;


plus:

* past persistent diarrhea >14 days’ duration, and excluding current constipation.


We have over the last 10 years evaluated several thousand children on the autistic spectrum who have significant gastrointestinal symptoms. Upper and lower endoscopy and surgical histology have identified mucosal inflammation in excess of 80% of these children. Almost none of these children with biopsy-proven enterocolitis would fit the criteria set out above. Firstly, these children rarely have vomiting, current weight loss (as opposed to failure to gain weight in an age-appropriate manner), or passage of blood per rectum. The requirement is thus narrowed to a child having two of two relevant symptoms – current persistent diarrhea and current abdominal pain according to their criteria, plus a past history of persistent diarrhea excluding current constipation.

The requirement for the current presence of these symptoms, for 14 or more days continuously, shows a singular lack of understanding of the episodic, fluctuating, and alternating (e.g. diarrhea/constipation) symptom profile experienced by these children. In our experience, ASD children with histologic enterocolitis typically have 1 to 2 unformed stools per day that are very malodorous and usually contain a variety of undigested foodstuffs. This pattern alternates with that of “constipation” in which the unformed stool is passed after many days of no bowel movements at all, and with excessive straining. This group is entirely overlooked by the arbitrary criteria set forth in their paper. With respect to diarrhea and constipation, a detailed discussion of stool pattern in these children is available1 which further highlights the shortcomings of the above criteria. Moreover, the interpretation of pain as a symptom in non-verbal children, as it often manifests as self injury, aggressive outbursts, sleep disturbances, and abnormal posturing, is notoriously difficult. This interpretation requires an insight based upon the correlation of symptoms, histological findings, and response of symptoms to anti-inflammatory treatment. There is no evidence in the Baird et al. paper that these crucial factors were taken into account. This study’s inappropriate symptom criteria would explain the discordance with other reports that have revealed a high prevalence of significant gastrointestinal symptoms in general autism populations2,3.

It is surprising that Dr Peter Sullivan, a co-author on the paper, who presumably provided the above gastroenterological criteria, was not aware of the aforementioned limitations. In his role as a Defendant’s expert in the UK MMR litigation, he will have had access to the clinical records of autistic children with the relevant intestinal symptoms and biopsy-proven intestinal inflammation.

We suggest that the authors might wish to reflect on the ethical implications of setting the bar too high for the investigation of such children by ileo-colonoscopy, with the attendant risk of missing symptomatic, treatable inflammation.

Since the relevant MMR/autism children are considered to be those with regression and significant gastrointestinal symptoms, the appropriate stratification for between-group analyses of measles virus antibody levels has not been conducted; therefore the paper is difficult to interpret, adding little if anything to the issue of causation. Moreover, it is a major error to have presumed that peripheral blood mononuclear cells are a valid ‘proxy’ for gut mucosal lymphoid tissues when searching for persistent viral genetic material.

A further major problem in this study is the number of children who dropped out or who were unable to provide adequate blood samples. We know nothing about either the 735 children who were lost at stage two, or the 100 children for whom blood samples were not available. At the very least, we should be told whether the children who dropped out were likely to be representative of those who stayed in, with regard to the key issues of interest.

For reasons that will emerge in the near future, it would be of interest to know whether siblings of autistic children were included in either of the two control groups. This information is not provided.

As a general observation, this paper contributes nothing to the issue of causation, one way or another. Case definition alone is likely to have obscured the relevant group of autistic children. The study tells us nothing about what actually happened to the children at the time of exposure. We are increasingly persuaded that measuring things in blood many years down the line tells us very little about the initiating events in what is, in effect, a static (non-progressive) encephalopathy unlike, for example, subacute sclerosing panencephalitis, which is a progressive measles encephalopathy. The gut is a different matter, and analysis of mucosal tissues has been very informative, since here, in the relevant children, active ongoing, possibly progressive [AV1]4, inflammation has been identified.

None of Wakefield’s pointers to the irrelevance of or inadequacies in the Baird research was included in the news stories. Nor do these stories refer to other research studies which show a higher rate of gastro-intestinal problems among children with autistic-spectrum symptoms. The recycling of the Baird study was but the latest in a steady drip-feed of such items which appear to be part of a concerted campaign to ensure that the General Medical Council hearing into the conduct of Wakefield’s research, which is shortly due to resume, takes place in as prejudiced an atmosphere as possible. No stone is being left unturned by the medico-political establishment and its creatures in the media to ensure that this doctor is destroyed.

As I have repeatedly said, I have no idea whether Wakefield is correct or not in his concerns about the possible adverse effects of the MMR vaccine on a small sub-set of vaccinated children. Nor do I know whether any of the charges being levelled against him at the GMC has any legs. But I do believe — as I wrote in my series of articles on the subject for the Daily Mail in 2003 here, here and here — that many of the statements made by the Department of Health and medical establishment about the ‘proof’ of the vaccine’s unchallengeable safety are deeply misleading. And I also believe, having spoken to many parents of such children, that their experiences simply cannot be dismissed as they have been by the medical establishment. No-one has ever suggested that the MMR vaccine causes all or most of the incidence of autism. If Wakefield is correct, it is only a small proportion of children whose immune systems may be unable to cope, for whatever reason, which makes them particularly vulnerable to such ill-effects. And contrary to the message being pumped out by the medical establishment that the vaccine has been proved to be safe — by studies which are all either flawed, inadequate or irrelevant — the fairest and most accurate thing to say is that the jury is still out.

One of the most reprehensible weapons being wielded in the witch-hunt against Wakefield is the claim that anyone who gives any credence whatever to his concerns is responsible for the incidence of measles amongst children whose parents are as a result too frightened to give them the MMR vaccination. There are two obvious points to make in response to this piece of moral blackmail: 1) the whole panic could have been avoided by offering single measles, mumps and rubella jabs rather than the triple MMR, and 2) it is surely just as important as avoiding cases of measles mumps and rubella to avoid causing the kind of catastrophic damage to the brain and gut displayed by the children at the heart of this controversy.

And there is a further and quite appalling point to note. This whole saga started because parents of such children found that their family doctors were dismissing out of hand their children’s gut and brain problems, accordingly refusing to alleviate their suffering. Now, as a direct result of the animosity towards Wakefield that has been whipped up — and the fear that any doctor who suggests he might be right will similarly find him or herself at the receiving end of the medical establishment’s fist — children exhibiting this combination of gut and brain damage are finding it difficult to obtain treatment.

Another letter to the Archive of Diseases in Childhood from John Stone, the parent of an autistic child, makes terrifying and distressing reading:

In this regard it is worth noting the recent warning of the National Autistic Society (NAS):

‘The National Autistic Society is keenly aware of the concerns of parents surrounding suggested links between autism and the MMR vaccine. The charity is concerned that the GMC hearing, and surrounding media coverage, will create further confusion and make it even more difficult for parents to access appropriate medical advice for their children. It is particularly important that this case is not allowed to increase the lack of sympathy that some parents of children with autism have encountered from health professionals, particularly on suspected gut and bowel problems. Parents have reported to the NAS that in some cases their concerns have been dismissed as hysteria following previous publicity around the MMR vaccine. It is crucial that health professionals listen to parents' concerns and respect their views as the experts on their individual children…’

The NAS warning relates to the GMC hearing involving doctors Wakefield, Walker-Smith and Murch which is set to resume on 25 March approaching. I do not think it is being unduly cynical to query the publication of this study at the present time as a media event, bearing in mind that it seems to have been carried out five or six years ago. Moreover, the study has once again been promoted as refuting the Wakefield hypothesis when it in fact tests for a possibility that had not been proposed. Meanwhile, the plight of autistic children with gastro- intestinal symptoms is excluded both from the study and public attention, as if they did not exist. The NAS statement warned of ‘creating further confusion’ and this is precisely what this study and its media exposure has done.

As the resumption of the GMC hearing draws nearer, one has to ask whether this will serve the cause of truth and justice and the relief of suffering — or is it instead merely a show trial which will bring about the precise opposite?

Mito/DNA/Autism/GFCF/Glutamate Thoughts From A Food Process Engineer

Now THIS is the kinda thing I was talking about in my fantasy "Responsible Government" piece. Medical professionals hearing the mito/autism news and applying their understanding from other fields to the autism problem! It even has autism gene theory with, get this, real world application that can be of use for helping kids today!

Except in my fantasy she would not have to be posting this to a CNN site, because NIH would have called her when she sent it into them months ago.

Another fascinating Dr. Gupta comment:

Dr. Gupta,

Here is what I wrote to the NIH in January. It still sums up my thoughts. It should be noted that one of the genes for autism discovered last year codes for a MITICONDRIAL aspartate/glutamate carrier.

I am a former food process engineer who believes, because recent studies have implicated genes which code for glutamate synapses in ASD, we should investigate the effects of both INGESTED and INJECTED excitatory free amino acids (glutamic acid and aspartic acid) on children with these autism genes.

If excitatory free amino acids affect ASD children, it would explain both the impact of GF-CF diets AND a vaccine link. Vaccines have free glutamic acid added to preserve the virus. I have created and attached a chart showing where free glutamic acid comes from. It is found in extremely high amounts in processed wheat and dairy products so much so that food manufacturers use these two items routinely to produce free glutamic acid in foods but with a clean label.

Consequently, a child may not improve on a GF-CF diet alone, because it doesn’t limit all potential sources of free glutamic acid like soy. Children are tested at birth for PKU and phenylalanine is limited until the brain is hardwired by the age of 7. Why not treat the predisposition for autism similarly and limit the glutamic and aspartic amino acids in the diets of children with autism genes?

ASD also includes errors of metabolism for sulfur containing amino acids like cysteine. Cysteine is converted to taurine and glutathione by the liver. Taurine regulates heartbeat and osmotic balance as well as bile production and was found to be low after a seizure. In ASD, symptoms include arrhythmias, digestive disorders and a high rate of epilepsy, suggesting that taurine production may be compromised. Glutathione levels are also lower in ASD leading one to conclude that possibly, cysteine metabolism may be responsible for the myriad and seemingly unrelated additional symptoms of ASD. It should be noted that glutamate interferes with the handling of cysteine. When cysteine metabolism is compromised, homocysteine levels may increase. The lower levels of glutathione may put ASD individuals at risk of mercury poisoning, since glutathione helps eliminates mercury from the body.

It should be noted that the NMDA receptors that respond to both glutamate and aspartate are found in the amygdala - part of the limbic system involved in the perception of taste and smell as well as fear. Activating the amygdala in ASD, causes gaze avoidance. ASD children may also over-react to smells and tastes and face to face encounters can overwhelm them with fear. Limiting excitatory amino acids that target the amygdala may help.

Japan consumes more MSG, and fish (a dietary source of mercury) than nearly any other country. Compared to the amount of mercury consumed in fish and the amount of MSG consumed in the diet, the MMR contribution was probably small compared to a typical Japanese diet. In Japan, the MMR vaccine was stopped in 1993. Autism rates still increased. Perhaps in Japan, the diet plays more of a role in autism than the vaccines. Children from other countries with a lower consumption of fish and MSG may find a stronger correlation between vaccines and autism.

New research studies into ASD should include people who are sensitive to the food additives MSG and aspartame. MSG-sensitive persons have reported a distinct lessening of symptoms by using taurine, ibuprofen, CoQ10, Vitamins B6 and B12, carbohydrate, foods high in butyric acid like butter, and Magnesium. Perhaps they share some of the same genes that predispose a child to ASD. New treatment studies should look into these easily available, inexpensive and relatively safe compounds.

Based on what I have observed, here are my recommendations:

1. Treatment of ASD?

REMOVAL of excitatory amino acids (glutamate, aspartate) from VACCINES.
Glutamate and aspartate restricted diet (similar to treatment for PKU) in addition to GF/CF diet.

Supplementation of taurine, glutathione, vitamins B6, C, magnesium, CoQ10.
Increased carbohydrate.

Labeling of free glutamic and aspartic acid on food labels.
Glutamate blockers, anti-histamines and leukotriene blockers for children already suffering or getting vaccinated.

We should calm their surroundings, encourage quiet tasks and less-threatening contact to enhance communication. We need to give them space and not overwhelm them.


2. Diagnosis of ASD?

Test for autism genes preferably AT BIRTH like PKU.

Tests for aspartic acid, glutamic acid, glutathione, taurine, cysteine, homocysteine.


3. Risk factors for ASD?
Autism Genes
Sensitivity to excitatory amino acids
Low taurine, Low glutathione
Sulfite Sensitivity
Vaccination with glutamic acid as a preservative
Damage to the microglia
Overactive immune system
Junk food diet
Aspartame in medications or vitamins or foods
Multiple food allergy


4. Biology of ASD?

Excess CNS sensitivity,

Inability to handle sulfur-containing amino acids,

Overactive immune response linked to Nerve Growth Factor


5. Other areas of ASD research?

Common genes in Alzheimer’s, Parkinsons, ALS, MS, and excitatory amino acid sensitivity.

Study persons without ASD who suffer from overactive CNS or neurodegenerative disease and sensitivity to excitatory amino acids. See if they share same genes.

Could Alzhemier’s sufferers simply be ADS children whose brains were hard-wired before damage by the environment?


Thank you for this opportunity to share my ideas on this very important topic,

Please see this webpage that clearly shows why a wheat and dairy based processed food diet may be very harmful to a child sensitive to excitatory amino acids:
http://www.msgtruth.org/avoid.htm

HT:Here in HP