December 14, 2008

Methyl B12 and Folinic Acid Raise Glutathione Levels in Autistic Children

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism.

James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW.

Departments of Pediatrics and Biostatistics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR.

BACKGROUND: Metabolic abnormalities and targeted treatment trials have been reported for several neurobehavioral disorders but are relatively understudied in autism.

OBJECTIVE: The objective of this study was to determine whether or not treatment with the metabolic precursors, methylcobalamin and folinic acid, would improve plasma concentrations of transmethylation/transsulfuration metabolites and glutathione redox status in autistic children.

DESIGN: In an open-label trial, 40 autistic children were treated with 75 mug/kg methylcobalamin (2 times/wk) and 400 mug folinic acid (2 times/d) for 3 mo. Metabolites in the transmethylation/transsulfuration pathway were measured before and after treatment and compared with values measured in age-matched control children.

RESULTS: The results indicated that pretreatment metabolite concentrations in autistic children were significantly different from values in the control children. The 3-mo intervention resulted in significant increases in cysteine, cysteinylglycine, and glutathione concentrations (P < 0.001). The oxidized disulfide form of glutathione was decreased and the glutathione redox ratio increased after treatment (P < 0.008). Although mean metabolite concentrations were improved significantly after intervention, they remained below those in unaffected control children.

CONCLUSIONS: The significant improvements observed in transmethylation metabolites and glutathione redox status after treatment suggest that targeted nutritional intervention with methylcobalamin and folinic acid may be of clinical benefit in some children who have autism. This trial was registered at as NCT00692315.

UPDATE: Some one provided me with a TIF of the full study.


acollage said...

Another enlightening post -- as always, great info. Keep 'em coming!

terrih77 said...

So does mean their behaviours improved?

Ginger Taylor said...

It doesn't look like the behaviors were measured.

Someone just sent me a tif of the full study. I will post it.

gina said...

To my knowledge, food consumed during growth can't be ruled out as an environmental cause of metabolic abnormalities because safety testing has not been done.

GMW: One Gene, One Protein, One Function - NOT
By Greg Revell
Science Alert, December 15, 2008

With the abrupt and uninvited introduction of genetically modified (GM) food into our supermarkets and restaurants, many of us are looking more closely into the food we eat...

Ginger Taylor said...


Take a look back at the GMO pieces I wrote in the spring about a potential link to GMO foods and autism.

gina said...

This pro bono research you are doing is going to result in a much needed seismic shift and will change the world. I have absolutely no doubt about it.

Your posts on May 2, May 3, May 7 and August 11, 2008 could be the basis for an outstanding stand-alone blog on GMO foods. Links in the comments section don't post correctly, but fortunately your site's search engine is great and brings them up during a search for 'gmo foods.' I hope everyone reads the posts carefully, watches the videos and helps spread the word.

Thanks for all you do. Have you seen this?

The Time Is Now for a Green Revolution By Bonnie Raitt

...The green revolution stretches across all party lines, generations and national borders. We have the solution to our problems right here, right now at hand. There has never been a more crucial time to stay involved.

Good ideas - I can imagine yet uncreated groups analogous to the Raging Grannies or Code Pink Women4Peace helping activist parents of children with autism with the division of labor by taking this issue offline and staging local protests.

The status quo is simply unacceptable.

gina said...


The status quo is totally unacceptable.

gina said...

Here's a book (available at Amazon)
I plan to read (since the author's website is only viewable in cache form, despite the online endorsement by 'one of the world's leading protein scientists and experts on GMOs, DR. ARPAD PUSZTAI': "We need to strengthen the GM skeptic base in the USA because whatever we may, here in Europe, do against this madness, the back of the GM industry will have to be broken in the USA. And your book is going to be a great help for this.")
Please search 'shedding light' for full book review.
May 29, 2008 – Shedding Light on Genetically Engineered Food by Beth H. Harrison, PhD is awarded 1st place (gold) winner 2008 “Outstanding Book of the Year—Most Progressive Health Book”

Independent Publisher (IPPY) Awards honor the year's best independently published titles; this year's contest attracted 3,175 entries. Shedding Light on Genetically Engineered Food was awarded 1st place gold medal winner of "Outstanding Book of the Year—Most Progressive Health Book," exhibiting "the courage and creativity necessary to take chances and bring about change, not only to the world of publishing, but to society…" This book also won an Eric Hoffer Award in health and two Next Generation Indie Awards in health/wellness and current events categories.

Shedding Light on Genetically Engineered Food delves into how some of the top corporations that control your food have repeatedly done business at the expense of public health.

Biotechnology scientists are changing the most fundamental characteristics of the food we eat without knowing what it will do to people who eat it. As far as US regulatory agencies are concerned, if a biotech company SAYS its products are safe, that is enough for approval.

An estimated 70-75% of processed foods on supermarket shelves—from soda to soup, snack food, cereals to microwave food, even baby food and infant formula—contain unlabeled GE ingredients. Yet GE foods have never been proven safe for human consumption.

In fact, nearly every independent laboratory animal feeding study on GE food shows adverse or unexplained effects. According to independent scientists, human health effects of consuming GE food can include toxic and allergic reactions, antibiotic resistance, immune suppression, and other serious illnesses...

CACHE containint Dr. Arpad Pusztai's quote:

Online review (New Zealand)

The best I can do to access the rest of the site
is to hit CACHED link from here:

Look at what happened here (and check paragraph 3 links for parallels to divisions within the autism community):

Scientists' Open Letter on the Hazards of Genetically Engineered Foods & Crops
Dec. 20, 2005

gina said...

Browsing the November 2008 archives, note Immoral Maize parts 1-3, a shocking chapter from the book Don't Worry (It's Safe to Eat) by Andrew Rowell:
"(Amazon review)...In tracing how critics are silenced in the bottom-line climate of commercialized science and privatized knowledge, Rowell tells the true story of the widely publicized Pusztai GM potato scandal of the late 1990s and the ongoing Mexican maize GM contamination affair. Finally, the book offers radical solutions to make science work in the public interest and provide food that really is safe to eat."


I took my car magnet down today,
it's up to us. Yes, we can.

gina said...

Please substitute for newly broken link above: