March 14, 2008

The Effects of Hyperbaric Oxygen Therapy on Oxidative Stress,

The Effects of Hyperbaric Oxygen Therapy on Oxidative Stress,
Inflammation, and Symptoms in Children with Autism: an Open-Label
Pilot Study

Daniel A Rossignol, Lanier W Rossignol1, S Jill James, Stepan Melnyk and
Elizabeth Mumper

International Child Development Resource Center, University of
Arkansas for Medical Sciences, Department of Pediatrics, Arkansas Children's Hospital Research Institute, Advocates for Children

Background: Recently, hyperbaric oxygen therapy (HBOT) has increased in popularity as treatment for autism. Numerous studies document oxidative stress and inflammation in individuals with autism; both of these conditions have demonstrated improvement with HBOT, along with enhancement of neurological function and cognitive performance.
In this study, children with autism were treated with HBOT at atmospheric pressures and oxygen concentrations in current use for this condition. Changes in markers of oxidative stress and inflammation were measured. The children were evaluated to determine clinical effects and safety.

Methods: Eighteen children with autism, ages 3–16 years, underwent 40 hyperbaric sessions of 45 minutes duration each at either 1.5 atmospheres (atm) and 100% oxygen, or at 1.3 atm and 24% oxygen. Measurements of C-reactive protein (CRP) and markers of oxidative stress, including plasma oxidized glutathione (GSSG), were assessed by fasting blood draws collected before and after the 40 treatments. Changes in clinical symptoms, as rated by parents, were also assessed. The children were closely monitored for potential adverse effects.

Results: At the endpoint of 40 hyperbaric sessions, neither group demonstrated statistically significant changes in mean plasma GSSG levels, indicating intracellular oxidative stress appears unaffected by either regimen. A trend towards improvement in mean CRP was present in both groups; the largest improvements were observed in children with initially higher elevations in CRP. When all 18 children were pooled, a significant improvement in CRP was found (p = 0.021). Pre- and post-parental observations indicated statistically significant improvements in both groups, including motivation, speech, and cognitive awareness (p < 0.05). No major adverse events were observed.

Conclusion: In this prospective pilot study of children with autism, HBOT at a maximum pressure of 1.5 atm with up to 100% oxygen was safe and well tolerated. HBOT did not appreciably worsen oxidative stress and significantly decreased inflammation as measured by CRP levels. Parental observations support anecdotal accounts of improvement in several domains of autism. However, since this was an open-label study, definitive statements regarding the efficacy of HBOT for the treatment of individuals with autism must await results from double-blind, controlled trials.


TSC said...

I have always believed that Hyperbaric Oxygen Therapy helps autistic children. I even made a comment on the blog about this on December 15, 2007

My comment regarding Autism Treatments on

"Considering that I believe this epidemic is caused by sleep apnea......I can see why many parents have found that both gluten free diets and hyperbaric chambers have been helpful."

"Considering that I believe this epidemic is caused by sleep apnea which is associated with acid reflux(on the same gene: Chromosome 13: 13q14) I can see why many parents have found that both gluten free diets and hyperbaric chambers have been helpful. Tonsillectomies, adenoidectomies, and nCPAP’s would probably be helpful too."

"Regarding the Autism Epidemic. In 1993 the SIDS Prevention Back to Sleep campaign was started. At that time about 13% of American babies slept on their back. Now, it is 76%. Back sleep causes more sleep apnea episodes (lack of oxygen) and decreases sleep duration by 6% to 8% compared to stomach sleep. Therefore, since 1993 tens of millions of babies in America (and 30+ other countries) have had 6% to 8% less sleep and more sleep apnea episodes. I personally think this is the cause of the autism epidemic."

"Just to follow-up on my previous comment: Sleep apnea has a 4:1 male to female rate. In severe cases of sleep apnea the rate is 10:1. This is because the upper airway anatomies of men and women are different. Sleep apnea can typically be cured by either a tonsillectomy with adenoids removed and/or an nCPAP (nasal Continuous Positive Airway Pressure) machine."

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