H1N1 Vaccine, Optic Neuritis and Disseminated Encephalomyelitis

Pediatr Infect Dis J. 2010 Aug 3. [Epub ahead of print]
ADVERSE NEUROLOGIC REACTIONS AFTER BOTH DOSES OF PANDEMIC H1N1 INFLUENZA VACCINE WITH OPTIC NEURITIS AND DEMYELINATION.

Lapphra K, Huh L, Scheifele DW.

From the *Vaccine Evaluation Center, Department of Pediatrics, British Columbia Children' Hospital, University of British Columbia, Vancouver, British Columbia, Canada; and daggerDivision of Neurology, Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Abstract

When a neurologic condition develops after vaccination of a patient, the causal relationship is difficult to determine. We report an unusual case in which neurologic signs occurred in a previously healthy child after both doses of H1N1 2009 influenza vaccine, culminating in bilateral optic neuritis and disseminated encephalomyelitis. A causal association is more likely with repeated injury following influenza vaccination.

PMID: 20686434 [PubMed - as supplied by publisher]