Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
Harumi Jyonouchia, Lee Genga, Deanna L. Streckb and Gokce A. Torunerb
Division of Allergy/Immunology and Infection Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey (UMDNJ)-New Jersey Medical School (NJMS), 185 South Orange Ave, Newark, NJ, United States
Institute of Genomic Medicine, Department of Pediatrics, University of Medicine and Dentistry of New Jersey (UMDNJ)-New Jersey Medical School (NJMS), 185 South Orange Ave, Newark, NJ, United States
Received 16 February 2011; revised 26 June 2011; accepted 6 July 2011. Available online 30 July 2011.
Abstract
Innate/adaptive immune responses and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N = 30). The ASD/Inf children with persistent gastrointestinal symptoms (ASD/Inf + GI, N = 19), revealed less production of proinflammatory and counter-regulatory cytokines with stimuli of innate immunity and marked changes in transcript profiles of monocytes as compared to ASD/no-Inf (N = 28) and normal (N = 26) controls. This included a 4–5 fold up-regulation of chemokines (CCL2 and CCL7), consistent with the production of more CCL2 by ASD/Inf + GI cells. These results indicate dysregulated innate immune defense in the ASD/Inf + GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes.
August 8, 2011
ASD, GI, Immune Abnormalities
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3 comments:
"rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes".
Funny how Feingold recognized that food additives and dyes could affect a certain subgroup of children, yet vaccines, with all of their additives, are perfectly ok for ALL children.....
You have NO idea how much I look forward to your blog posts, Ginger! <3
The Acrodynia (Pinks Disease) link with autism is further evidence that both an environmental toxin and a genetic predisposition are involved.
I sincerely hope that during your investigations you look at the relationship between APO-E4 geneotype focusing not only on thimerosal (ethyl mercury) but also amalgam dental treatment during pregnancy and maternal mercury/silver amalgam burden.
The APO-E4 geneotype is also associated with several adult onset neurological disorders linked to mercury in all its forms.
Boyd E. Haley, PhD published a very good reiew on the relationship between APO-E, a houskeeping protein that normally removes cholesterol from the brain, and mercury.
Haley "The relationship of the toxic effects of mercury to exacerbation of the medical condition classified as Alzheimer’s disease", Medical Veritas 4 (2007) 1510–1524
David Kennedy, DDS
Hi,
You may want to look at this website that shows that there has been research proving that vaccines could be the cause of autism:
http://www.wddty.com/dna-in-vaccines-linked-to-rise-in-autism.html
http://www.wddty.com/mmr-and-autism.html
Darius Soon
www.autismsingapore.com
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