Maine CDC Autism Conference: How Do We Know What Autism IS NOT if We Do Not Know What Autism IS? by Jon Poling, MD, PhD

Maine CDC Autism Conference 2009
Looking Forward Beyond Vaccines: How Do We Know What Autism IS NOT if We Do Not Know What Autism IS? Followed by Q&A with other conference speakers.
Jon Poling, MD, PhD
Neurologist, Clinical Assistant Professor
Medical College of Georgia
Father of child with autism

Jon Poling Corrects Paul Offit Again, This Time in the NEJM

A few months ago, Paul Offit told some mistruths about the Poling case in the NYT, and they ran Jon Poling's correction a few days later.

Offit has not stopped lying mistruthing and now Poling is correcting him publicly for a second time, now in the New England Journal of Medicine.

One of the errors that Offit keeps repeating is that the Poling judgment was a court decision (Offit's disciple Amanda Peet repeated this untrue statement on GMA yesterday), which I have heard him state repeatedly since Poling corrected him last spring.  Offit's assertion is that these decisions don't belong in the courts, but that they should only be made by doctors, which is exactly how the Poling case was made.  So then why would Offit be complaining about something that actually worked the way that he said it should work?

At first I thought that he was just not listening, assumed that it was a court ruling and just shooting his mouth off with out thinking.  But then I realized that he is not claiming that the Poling decision was a court case and dismissing court decisions to insulate the vaccine program from the Poling decision, he was doing it to insulate Vaccine Inc. from all the forth coming decisions from the Omnibus hearings and any of the other 5,000 cases pending in vaccine court.

He knows that petitioners will be awarded judgments by the court and he is trying to use his interviews on the Poling case front load his talking points that delegitimatize the "unusual vaccine court".

This is all IMHO of course.

New England Journal of Medicine  Volume 359:655-656 August 7, 2008

Vaccines and Autism Revisited

"To the Editor: In his Perspective article on a possible connection between vaccines and autism, Offit (May 15 issue)¹ speculates about my daughter, Hannah, and repeats inaccuracies from a March New York Times opinion piece that was officially corrected by the Times and our April 5 letter. By omitting critical information from my March 6, 2008, statement, Offit misrepresents my position. I said, "Many in the autism community and their champions believe that the result in this case may well signify a landmark decision as it pertains to children developing autism following vaccinations. This still remains to be seen, but currently there are almost 5,000 other cases pending."

Offit's remarks about Hannah's case are not evidence-based. He has no access to my daughter's personal medical records, legal documents, or affidavits. In contrast, physicians from the Department of Health and Human Services (DHHS) who studied this information recommended that the government concede Hannah's case. The clinical history Offit presents contains significant inaccuracies, and the resulting conclusions are consequently flawed.

Offit confuses issues by comparing Hannah's case with unrelated decisions in "vaccine court." The Office of the Secretary of DHHS, through the Department of Justice, conceded Hannah's case. There was no courtroom hearing and no decision from the "unusual vaccine court."

Offit is frequently cited regarding the "biologically plausible" theory that simultaneous administration of multiple vaccines is safe. His opinion is unsupported by clinical trials, much less investigations in potentially susceptible subpopulations.

Despite the high frequency of mitochondrial dysfunction in autistic children,² studies have not established primary or secondary roles. To explore this question, we need an immunization database for children with metabolic disorders to establish safety guidelines³ and improve vaccine safety for minority subgroups of children.

I agree with the statement of Bernadine Healy, former director of the National Institutes of Health, who said, "I don't think you should ever turn your back on any scientific hypothesis because you're afraid of what it might show. . . . If you know that susceptible group, you can save those children.

If you turn your back on the notion there is a susceptible group . . . what can I say?"⁴ Also commendable is the new 5-year research plan of the National Vaccine Advisory Committee, which will entail the study of minority subpopulations, including patients with mitochondrial disorders.⁵

A strong, safe vaccination program is a cornerstone of public health. Misrepresenting Hannah Poling v. HHS to the medical profession does not improve confidence in the immunization program or advance science toward an understanding of how and why regressive encephalopathy with autistic features follows vaccination in susceptible children.


Jon S. Poling, M.D., Ph.D.
Athens Neurological Associates
Athens, GA 30606
jpoling@athensneuro.com


Dr. Poling is the father of Hannah Poling and reports receiving consulting or lecture fees from Pfizer, Eisai, Ortho-McNeil, Biogen, Teva, Immunex, and Allergan. No other potential conflict of interest relevant to this letter was reported."

So now Offit has been twice publicly corrected in two of the highest profile publications in the world, and from here on out if we hear Offit repeat the "court case" misinformation, there can be no doubt that the man knows exactly what he is doing and he is just a flat out liar.

Yesterday at the "Vaccinate Your Baby" press conference Offit said that Bernadine Haley, former head of NIH who believes that the vaccine/autism link may be real and it should be the focus of study, must not have done her research, since she disagreed with him.  He continues to lie about the Poling case despite the recurrent corrections of Jon Poling a respected Neurologist with Johns Hopkins credentials.

I think Offit is so used to just saying whatever he wants about anyone that disagreed with his vaccine stance for a long time, with few consequences, because when he started years ago it was only powerless parents that he was degrading.  He does not seem to have noticed that now that respected people in main stream medicine are waking up to the problem, his blanket smearing of people who take the theory seriously, and lying about the facts is now a slap in the face of people much more respected than he is.

But I guess he has that book coming out in a month so there is no turning back for him.  He is all in and will be going out with a bang.

UPDATE:  Don't miss Anne Dachel's post on the matter over at Age of Autism. 

Round Up: NAA's FOUND, Poling Schools Novella, Too Many Sick Kids, More Outrage at Savage, Kirby on Peet, NZ Angry Over Expensive/Usless Vaccine

• The National Autism Association (NAA) has announced the launch of a new program called Found, aimed at providing families and counties nationwide with safety tools for children with autism which will immediately fund $54,400.00 to provide at least eight counties with Project Lifesaver equipment and tracking watches. The program was made possible by a huge donation from Pixies Train Ride and the half a million visitors to her site.  God Bless you Pixie!
• Dr. Jon Poling reminds Dr. Stephen Novella about the facts in his daughters case and requests that he refrain from attacking autism moms.
• Allison Edwards is outraged over all the sick little boys in the UK.
• Kim Stagliano takes another swing at Michael Savage over at the Huffington Post.
• Also on the Huffington Post, David Kirby with observations and more observations on the Amanda Peet kaffuffle.
• New Zealanders angry that $200 million was spent on a much hyped meningococcal vaccine that only protects 30% of users, for only 7 months, and that they were not given informed consent before taking the shot.
• Mercola on avoiding mercury and other metals.
  

WaPo Reports on Mitochondrial Disorders and Autism

Another article on John Shoffner's presentation.

I would like to call attention to the fact that mitochondrial disorders are not purely of genetic origin, but also the result of toxic injuries from ingredients found in vaccines like thimerosal and aluminum and also pesticides and medications like AZT.

I am of the opinion that one of the reasons that HHS didn't give Jon Poling a hearing on his daughter's autism/vaccine injury claims, and just conceded that her mito disorder plus vaccines triggered her autism, was that they knew he would be able to prove the whole process was started by her vaccines. His multiple hit theory that her first round of shots gave her the mitochondrial disorder and her last interacted with them to trigger the autism is probably right, and they know it, so best to keep part one of the process underwraps and still try to get away with calling it a 'rare genetic condition' even if they had to admit to the last part.

The media is apparently not ready to report that these mitochondrial dysfunctions that interact with vaccines to cause autism as in Hannah's case, can themselves be triggered by an earlier round of shots, but I am sure that someone will get bold and report it soon.

Things are changing faster and faster as Kent Heckenlively so eloquently expressed when he compared the fall of the 'no link' party line and it's CDC proponents to the exponentially speedy fall of communism.

BRING ON THE CONGRESSIONAL HEARINGS!

UPDATE: Boyd Haley, Ph.D. Chemistry Department Chair at the University of Kentucky checks in.

"The research of Dr. Jill James showing lower reduced glutathione levels in autistics is a very strong indication that these children are suffering from oxidative stress. Dr. Woody McGinnis has research that indicates this also. Low glutathione can be caused by many toxic insults , including viral, bacterial and heavy metal or organic toxicants. Old men with muscle wasting disease have low glutathione levels which can be treated with some effectiveness with melatonin according to a past publication. Melatonin reportedly (Dr. Bernie Rimland) was one item that helped many autistics. Basically, I think that treating glutathione production by appropriate (and I don’t know what that is at this time) supplementation and removing any toxicant involved would be the best approach towards improving these children." - Boyd Haley

and

"Regarding “the cause for mitochondrial disorders quest” just google or medline ‘mercury effects on mitochondria’. Researchers have made careers looking for genetic causes of mitochondrial disorders in certain patients without ever eliminating the likely possibility that these individuals are mercury toxic or toxic with some other heavy metal. Trust me, not one single genetic screen of individuals with mitochondrial disorder will have included a survey of the number of dental amalgams the individuals had---and mercury from amalgams accounts for about 80% of the total mercury body burden. Now, consider that 85% of dentists have abnormal porphyrin profiles that indicate they are mercury toxic as do a large percentage of autistic children. The site of inhibition of the porphyrin profile is on the inner mitochondrial membrane---so mercury is in the mitochondria and doing biological damage on porphyrin (or heme) synthesis and WE DON’T KNOW ALL OF WHAT ELSE IT IS DOING. But we do know that in tests both the citric acid cycle and the electron transport system (ETS) are dramatically inhibited by low levels of mercury." - Boyd Haley

Muscle Weakness Found in Some Autistic Children
By Serena Gordon
Washington Post
Sunday, April 13, 2008; 12:00 AM

SUNDAY, April 13 (HealthDay News) -- New research suggests that muscle weakness in a child with autism may point to an underlying genetic defect that's causing mitochondrial disease, which means the muscles don't get the energy they need.

Conversely, it's possible that the mitochondrial disease may also play a role in the development of autism, perhaps by preventing the brain from getting the energy it needs to perform properly, the researchers noted.

"In large studies of kids with autism, about 20 percent have markers of mitochondrial disease in the blood," explained Dr. John Shoffner, an associate professor of biology at Georgia State University and president of Medical Neurogenetics.

Shoffner recently completely a retrospective analysis of 37 children with autism spectrum disorders and found that 65 percent of these children -- children who had been referred to him because their doctors suspected additional problems -- had mitochondrial defects.

He was expected to present the findings April 13 at the American Academy of Neurology's annual meeting, in Chicago.

Mitochondria are found in every cell of the body, with the exception of red blood cells, according to the United Mitochondrial Disease Foundation (UMDF). Mitochondria are vital to survival, because they make oxygen available to cells and metabolize food into energy for cells to thrive. Defects in mitochondria can lead to cell injury, or even cell death, according to UMDF.

Symptoms of mitochondrial disease depend on which body system is affected but may include muscle weakness, loss of muscle control, poor growth, heart disease, diabetes, developmental delays, an increased risk of infection and more.

Shoffner said that the mitochondrial energy production system is the only one in the body that requires two genomes to work -- genes inherited from both the mother and the father, and genes exclusively from the mother. "To make this system work, it requires a lot of genes. Hence the opportunity for lots of problems," said Shoffner, who added that there are several hundred known mitochondrial disorders.

Twenty-four (65 percent) of the children included in this study had genetic defects in their skeletal muscles. However, that doesn't mean that 65 percent of children with autism likely have mitochondrial disease. This was a select population of kids with autism, ones that had specifically been referred, because their doctors suspected a problem.

But, Shoffner pointed out that as many as one in five youngsters with autism spectrum disorders have shown signs of mitochondrial disease.

"If you're talking about 20 percent of kids with autism, that's a whole lot of children, and may represent an important segment of the autism spectrum disorder population. And we may be getting a foothold into the underlying cause of autism spectrum disorders," he said, adding, "This is a really important step forward that lets us put effort into understanding the mechanisms of disease."

"This study is a call to action. We need to know what is the real prevalence of mitochondrial conditions in children with autism," said Geraldine Dawson, chief science officer for Autism Speaks. "The more we can identify these subgroups of kids, the more we're going to parse apart the many forms of autism. This gives us clues to etiology."

"If we find that mitochondrial disease is a prevalent condition, having a better understanding of the kinds of symptoms that children may show if they have it might be helpful for parents," she said.

Shoffner said these findings may also open up new avenues of research into potentially more effective treatments for the future.

...

SOURCES: John M. Shoffner, M.D., associate professor, biology, Georgia State University, and president, Medical Neurogenetics, Atlanta; Geraldine Dawson, Ph.D., chief science officer, Autism Speaks; April 13, 2008, presentation, American Academy of Neurology annual meeting, Chicago

Jon Poling: Mitochondrial Dysfunction Not Rare In Autism

Dr. Poling suggesting medically defining "Mitochondrial Autism". I have been calling it "Poling Syndrome".

No matter what it is called, "what Hannah has" has been determined by HHS to be a vaccine injury. It is time for the medical community to define it, find what the percentage of kids with it are, screen for it and catch it before it descends into the "symptoms of Autism".

And if the medical authorities won't hear it from me, hear it from Jon Poling:

"As a neurologist, I have cared for those afflicted with SSPE (a rare but dreaded neurological complication of measles), paralytic polio and tetanus. If these serious vaccine-preventable diseases again become commonplace, the fault will rest solely on the shoulders of public health leaders and policymakers who have failed to heed the writing on the wall (scribbled by my 9-year old daughter)."

Reform the vaccine schedule before everyone abandons it.

Father: Child's case shifts autism debate
By Jon S. Poling
For the Journal-Constitution
Published on: 04/11/08

Autism in the U.S. has reached epidemic levels, at 1 in 150 children. Dr. Julie Gerberding, director of the Centers for Disease Control and Prevention, has recently upgraded autism to "an urgent health threat." The most contentious issue of the autism debate is the link to routine childhood vaccines. My daughter's case, Hannah Poling v. U.S. Department of Health and Human Services, has changed this debate forever. Hannah has pointed us in a new and promising direction —- the mitochondria.

On Nov. 9, 2007, HHS medical experts conceded through the Department of Justice that Hannah's autism was triggered by nine childhood vaccinations administered when she was 19 months of age. This concession was granted without any courtroom proceedings or expert testimony, effectively preventing any public hearing discussing what happened to Hannah and why. Contrary to some reports, the Special Masters, "judges" who preside over the "vaccine court," did not issue a decision.

Four months later, on March 6, with trepidation my wife, Terry, and I stepped forward to announce this news —- providing hope and awareness to other families. The HHS expert documents that led to this concession and accompanying court documents remain sealed, though our family has already permitted release of Hannah's records to those representing the almost 5, 000 other autistic children awaiting their day in vaccine court.

Mitochondria key

To understand Hannah's case, it is important to understand mitochondria, which act like batteries in our cells to produce energy critical for normal function. Because the government's concession hinged on the presence of Hannah's underlying medical condition, mitochondrial dysfunction, some claim the decision is relevant to very few other children with autism. As a neurologist, scientist and father, I disagree.

Emerging evidence suggests that mitochondrial dysfunction may not be rare at all among children with autism. In the only population-based study of its kind, Portuguese researchers confirmed that at least 7.2 percent, and perhaps as many as 20 percent, of autistic children exhibit mitochondrial dysfunction. While we do not yet know a precise U.S. rate, 7.2 percent to 20 percent of children does not qualify as "rare." In fact, mitochondrial dysfunction may be the most common medical condition associated with autism.

Biological markers

Although unlikely, if the Portuguese studies are incorrect and mitochondrial dysfunction were found to be a rarity occurring in less than 1 percent of all autism, it would still impact up to 10,000 children (250,000 worldwide), based on current estimates that 1 million people in the U.S. (25 million worldwide) have autism. If, on the other hand, the research showing that 7.2 percent to 20 percent of children with autism have mitochondrial dysfunction is correct, then the implications are both staggering and urgent.

Autism researchers do not currently understand whether mitochondrial dysfunction causes autism or is simply a secondary biological marker. Autism clearly has many different causes, and should really be separated into multiple autism(s). I propose that we clearly identify and research the subpopulation term of "mitochondrial autism," which is distinguished by its unique biological, but not genetic, markers.

Based on what we know now, it is time to follow the prestigious Institute of Medicine 2004 report regarding autism and vaccines:

"Determining a specific cause (for autism) in the individual is impossible unless the etiology is known and there is a biological marker. Determining causality with population-based methods requires either a well-defined at-risk population or a large effect in the general population."

A paradigm shift

When the IOM report was published, mitochondrial dysfunction defining an autistic subpopulation was not firmly established. Today there is no doubt that mitochondrial dysfunction represents a distinct autism subpopulation biological marker. I urge health officials and the IOM to embrace their own report and pursue this breakthrough in the science of autism. National public health leaders, including those at CDC, must now recognize the paradigm shift caused by this biological marker with regard to their current position of dispelling a vaccine-autism link.

In light of the Hannah Poling concession, science must determine more precisely how large the mitochondrial autism subpopulation is: 1 percent, 7.2 percent, 20 percent?

Based on the 2004 IOM analysis, if the mitochondrial autism subpopulation is found to be relatively uncommon, then all conclusions from prior epidemiological studies refuting an autism-vaccination link must be discarded. New studies then need to be performed exclusively with the mitochondrial subpopulation. If mitochondrial autism turns out to be common, then we could re-analyze the data from prior studies to determine if these studies were powered sufficiently based on a predicted effect size. If not powered appropriately, the conclusion refuting an autism-vaccine link would again have to be rejected. These statistical concepts are basic.

The current vaccine schedule, co-sponsored by the CDC and the American Academy of Pediatrics, injures a small but significant minority of children, my daughter unfortunately being one of those victims. Every day, more parents and some pediatricians reject the current vaccine schedule. In an abundance of caution, meaningful reform must be performed urgently to prevent the re-emergence of serious diseases like polio or measles.

Need for research

As a neurologist, I have cared for those afflicted with SSPE (a rare but dreaded neurological complication of measles), paralytic polio and tetanus. If these serious vaccine-preventable diseases again become commonplace, the fault will rest solely on the shoulders of public health leaders and policymakers who have failed to heed the writing on the wall (scribbled by my 9-year old daughter).

The mitochondrial autism scenario that my daughter has so eloquently painted has the CDC and public health experts logically cornered. Denial and fear tactics won't close Pandora's Box. Whether we find that mitochondrial autism is rare or common, there is urgent research left to be done to fully understand the interrelationship of vaccines, autism and mitochondria.

Reform of the vaccine schedule will be an important part of the solution, whether vaccines play a major or minor role in autism. Our public health agencies and programs need a reconstruction plan. Day one of the reconstruction hopefully starts at the Vaccine Safety Advisory Committee's Working Group, to be held at HHS headquarters today in Washington.

Dr. Jon S. Poling is a practicing neurologist in Athens and clinical assistant professor at the Medical College of Georgia.

Polings Prove, Once Again, That Paul Offit Does Not Have A Clue

I am at the DAN! conference and this morning one speaker said, "Thank God for the Hannah Poling case". She was met with a big round of applause from the audience.

Vaccines, Autism and Our Daughter, Hannah
Jon Poling and Terry Poling
The New York Times
April 5, 2008

Re: “Inoculated Against Facts,” by Paul A. Offit (Op-Ed, March 31):

Our daughter, Hannah, developed normally until receiving nine vaccines at once. She immediately developed a fever and encephalopathy, deteriorating into what was diagnosed, based on the Diagnostic and Statistical Manual of Mental Disorders, or D.S.M. IV, as autism.

The federal government, not an “unusual court,” made the concession. The decision wasn’t “careless,” as your subheading called it. It was based on a thorough review of Hannah’s records by Health and Human Services doctors.

The National Vaccine Injury Compensation Program does rely on a “preponderance of evidence” standard, which Hannah’s case met. It doesn’t necessarily compensate families “quickly, generously and fairly.” We filed our claim six years ago, pain and suffering are capped at $250,000, and Hannah has yet to receive compensation.

Dr. Offit’s assertion that “even five vaccines at once would not place an unusually high burden on a child’s immune system” is theory and risky practice for a toddler’s developing brain. No one knows if Hannah’s mitochondrial dysfunction existed before receiving vaccines. Dr. Offit’s claim that Hannah had “already weakened cells” is unfounded.

We support a safe vaccination program against critical infectious diseases. We need straight facts, serious science and speedy answers on these important issues.

Jon Poling
Terry Poling
Athens, Ga., April 3, 2008

Jenny McCarthy and David Kirby on Larry King

Tonight was another hallmark in the national vaccine/autism debate.

Never before has there been REAL debate.

A pissed off autism mom, a smart investigative journalist asking the hard question, an experienced pediatrician frustrated with his own profession, all face to face with hard core denial doctors like Harvey Karp and my pal David Tayloe who does not believe that vaccine injury even exists, and does not know how to read vaccine safety package inserts.

I have never seen David Kirby, usually the mellow, middle ground man, calling for more study, and 'let's see where things go', be so passionate. "The Debate Is Over"!

The very mature and measured Jon Poling could only shake his head at the AAP doctors misinformation.

Jay Gordon was clearly working hard to hold back his annoyance with his own AAP's party line and their lack of ability to reason beyond "vaccines good... make public health good...", to the varying health needs of individual children.

I have to guess that the Kirton's were booked on the show to make the 'genetics' point, and I have to wonder if they were disappointed when John Kirton said the word, "vaccines".

And then there is Jenny... shouting "Bullshit"!

And then there is my husband and me, jumping up and down in our living room!!!!

NOW the main event has started!

I want 10 more shows like this, but with fewer guest and with Larry asking questions that progress the debate a little better. ("Why do you keep having children?" Seriously Larry?)

Let me say outright, I cannot imagine for the life of me why the AAP has chosen David Tayloe as their new chief. He is a PR nightmare for them! In the current climate, when every day more and more parents quit vaccinating all together, choosing a dinosaur like Tayloe who is stuck in the 1950's polio epidemic, and who does not seem to notice that the threats to children's health have dramatically changed in the last half century, is just plain stupid.

I am going to say something here... and it will be the most harsh thing I have ever said about anyone on this blog before, but it needs to be said.

Dr. Tayloe said that in his practice that has seen 100,000 patients that he has never referred one person to the Vaccine Injury Compensation Fund. If he has never seen a serious vaccine injury, it is not because he has not come across one, it is because he has his head up his ass.

Tayloe is just dangerous.

This man has GOT to be removed from the position that he has been elected to before he takes office. I would take Karp in a second over this guy. Karp was wrong, but he wasn't crazy person saying insane things with a smile wrong.

Jay Gordon gives me hope that there are doctors out their who recognize that we have gone to far with vaccines and it is time to re-examine.

RISE UP WISE AND COMPETENT PEDIATRICIANS EVERYWHERE! RISE UP! Who do you want to take recommendations from, Jay Gordon, or David "The Dinosaur" Tayloe?

I know I am biased, way biased, but our guys won and the other guys just looked foolish.

Question of the evening goes to David Kirby who exposed the AAP docs for the close minded relics that they are:

David Kirby: "There is a bill in congress to study vaccinated v. unvaccinated populations in this country. Doctor would you support that legislation?"

David Tayloe: "Please allow me to talk around the answer by saying something politically correct but not going on record for supporting the legislation."

Jenny McCarthy: "Will you support the vaccinated v. unvaccinated study?"

David Tayloe: "We support lots of things, like flowers, and lemon drops and My Little Pony."

Yeah... they don't support that legislation.

The quote of the evening goes to David Tayloe who, when Jenny pointed to the chart of 36 vaccines and asked, "Do we really need ALL of these?", nodded his head and replied, and this is really great... listen to this:

"They're recommended!"

Well Doctor Tayloe... if 12 guys in Atlanta who tell mom's with good questions like, "Why don't you make a recommendation for pregnant women to receive only thimerosal free flu shots?", to sit down and stop asking questions in public vaccine policy meetings designed to let the public ask questions, then dammit... that is good enough for me! Bring on the vaccines!

36 Vaccines! It's Recommended!



(Check this space for more footage when I get around to it.)

[UPDATE: OMG! Turns out the Vaccine Injury Compensation Court exists in part due to the 3.5 million dollar malpractice suit that Dr. David Tayloe lost in 1985 when a child he gave the DPT shot to magically got permanent brain injury!! That Asshole just got on TV and implied that he had never SEEN a vaccine injury in his practice!!!

Here is what he said:

Tayloe: "I have yet to see a patient who I sent to the compensation program because I thought they had a permanent injury. Extremely rare."

He lost 3.5 million dollar lawsuit, apparently one of the biggest awards ever, the year before the vaccine court was created!

And then BRAGGS about not sending any other children to the injury program?!

And having a court force him for giving a shot to a kid who could not handle it was still not enough to teach him the lesson that not all vaccines are safe for every child, because he went on the Today show and said that ALL VACCINES ARE SAFE FOR EVERY CHILD!!!!

AAP you have lost your collective mind putting this man in charge!? Are you kidding me!!!! I think I am gonna have an aneurysm.

[More UPDATES: Gotten more information that this may have been Tayloe's father David Tayloe Sr. Which would make David Tayloe Jr. a little less evil, but sill evil. I am trying to confirm details but I am traveling today and only have like 10 more minutes of wifi.]

[YET MORE UPDATES: Thanks for your patience as I got reconnected after a day of travel. I got an email from someone Tayloe went to med school with that says this was his father. In thinking about where to adjust my judgmentalism meter, I think that I will retract my declaration that he is an asshole, and say that he is a dangerous, foolish man.

A jury told his own father that he was more than three million dollars worth of wrong for administering a shot that plunged a boy into brain damage, and he learned nothing from it, continuing to claim that 'all vaccines are safe for every child', and that there is no such thing as serious vaccine injury. (or maybe, but barely ever, as his statement last week was that there was not "any relationship between vaccines and permanent injury", and this week he has downgraded his stance to "extremely rare".) Even though it was not directly his, he should still know better because of his father's legacy.]

Info on David Tayloe's Malpractice Suit [HT: Kevin Barry]:

Medical Malpractice/Negligent Administration of the DPT Vaccine
$3,500,000 Jury Verdict, May 1, 1985


The Minor Plaintiff, Bernard Forehand, Jr., was seriously injured when the Defendant Pediatrician's Nurse failed to communicate to the Defendant Pediatrician, David Tayloe that the Minor Plaintiff had an adverse reaction to the first vaccination shot. The administration of the second shot left the Minor Plaintiff with a significant brain injury. The Defendant Pediatrician, David Tayloe, who at that time was the President of the National Pediatric Association, strenuously fought this case all the way to a jury verdict. On May 1, 1985, the jury handed down what was at that time the largest jury verdict in a medical malpractice case in the State of North Carolina, in the sum of 3.5 million dollars.

***********

Following is a newsletter article that I (Barbara Loe Fisher) wrote in the summer of 1985 on the Forehand lawsuit:

"In May, a North Carolina jury in the Wilmington U.S. District Court decided that David Tayloe, M.D. and T. Frank Stallings, M.D., of Washington Pediatrics, P.A., were guilty of medical malpractice in the pertussis vaccine-induced brain damage suffered by Beau Forehand, Jr. The child was awarded $3.5 million in compensatory damages by the jury but the judge overturned the verdict and it was appealed.

It was the highest medical malpractice award in North Carolina history. Beau was represented by attorneys Anne Werum Lambright and Richard Polling of the Charleston West Virginia firm of Preiser and Wilson. The defense claimed that the two doctors were following the vaccination guidelines contained in the American Academy of Pediatrics 1970's "Red Book" which was in effect at the time Beau Forehand received his first DPT shot in January of 1974.

Beau reacted to his first short with a 103 degree fever and inconsolable crying, which his mother reported to the doctors. Six weeks later, Beau had a febrile seizure and was hospitalized. However, despite the reaction to his first shot and the subsequent seizure, he was given another DPT shot even though he had a cold and a slight fever at the time of the second vaccination. Within three hours of his second DPT shot he went into a major seizure and has had an uncontrolled seizure disorder ever since. He was left with severe mental retardation.

The 1970 RedBook did not list inconsolable crying, a fever of 103 degrees, a history of convulsions or a cold at the time of vaccination as contraindications to the pertussis vaccine. Attorney Lambright stated that the jury's verdict in the case sent a clear message to physicians that "The American Academy of Pediatrics Red Book should not be used as the sole guide to contraindications or adverse reactions to vaccines. The basic premise in the Forehand case is that doctors have to use their common sense, medical training, skill, knowledge and experience to make appropriate determinations for vaccination on a case by case basis."

If the jury's verdict is upheld on appeal, the Forehand case will be an important precedent-setting case. It would mean that individual physicians are responsible for obtaining knowledge and making decisions about the advisability of vaccination in individual cases which go beyond automatic reliance on the recommendations listed by the AAP or the CDC's Advisory Committee on Immunization Practices (ACIP). Examples of additional information available to physicians are the vaccine manufacturer's product inserts included in vaccine packages. which historically have listed more contraindications than those listed by either the AAP or ACIP, and the more than 40 years of scientific literature on the subject."

In a Winter 1986 newsletter, I wrote:

"On September 18, 1986, Forehand V. Tayloe and Stallings was settled for $1.1 million in North Carolina. A North Carolina jury had concluded that two pediatricians were negligent in the pertussis vaccine induced brain damage of Beau Forehand, Jr. and had awarded the boy and his parents $3.3 million. The judge overturned the verdict and the case was appealed on behalf of Beau by the law firm of Preiser and Wilson, of Charleston, West Virginia, before the Sept. 18 settlement ended the lawsuit."

BRIEF VACCINE INJURY COMPENSATION SYSTEM (VICP) BACKGROUND:

The Forehand settlement was one of a series of DPT vaccine malpractice cases against negligent physicians, as well as a few high profile punitive damage awards for DPT vaccine brain damage that went against vaccine manufacturers between 1981-1985 which persuaded Congress that both drug companies making vaccines and doctors giving vaccines should be protected from liability for vaccine injuries and deaths. The vaccine manufacturers threatened to leave the country with no vaccine if they did not get protection. Doctors threatened to stop giving vaccines if they weren't protected. Both doctors and the companies wanted a federal compensation system that banned all vaccine injury lawsuits for all time. We fought for protection of the right to access the civil justice system to sue companies or doctors if the child was turned down for federal compensation or offered too little or if it could be proved the vaccine manufacturer engaged in criminal fraud or gross negligence in the manufacture the vaccine or the doctor did the same in administering the vaccine.

I hope this is helpful.

Best,
Barbara Loe Fisher

Dr. Poling Responds To Autism/Vaccine Nay Sayers

Dr. Stephen Novella on his blog NeuroLogica has posted his evaluation of the Poling case and why he believes it does not support the vaccine autism connection.

Dr. Jon Poling has responded as seen on The Age of Autism countering the arguement and expanding on the information that has been available publicly on the case.

It is a discussion between two neurologists and I will need to read them each 5 times before I can even begin to comment on the conversation.

But I will note two things.

First, I am impressed that Dr. Poling lists his potential conflicts of interest at the end of his letter. I think that every medical professional should do that as a part of their signature (For example I would sign Ginger Taylor, B.S., M.S., Mother of regressive autistic child who suspects vaccines had a causal relationship to ASD, Has Google Ads on her autism blog).

Second, for all of his in depth analysis of the medical facts in this case, Dr. Novella failed to correctly discern the sex of the child in question. He refers to Hannah several times as "he" and "the child", never as a female. He criticizes David Kirby's articles about the case, but did not read them thoughtfully enough to see that Mr. Kirby was clearly talking about a girl.

I will reserve this space for further comment as I come to understand this case further.

I will post both pieces:

Has the Government Conceded Vaccines Cause Autism?
Published by Steven Novella

No. But David Kirby and other anti-vaccinationist ideologues and members of the so-called mercury militia would like you to think so. For background, the Autism Omnibus refers to a set of hearings before the Vaccine Injury Compensation Program regarding claims by about 5000 parents that their childrens’ autism was caused by vaccines. These claims are primarily based upon the various hypotheses that the MMR vaccine, or thimerosal in some vaccines (but not MMR), or the combination of both, is a cause of autism.

So far there have been hearings, but only one final decision. In November the US government settled one case in favor of the petitioner. This is the case those who have supported the failed hypothesis that vaccines cause autism now point to as admission that they were right all along (or at least as a means of stoking the flames of fear about vaccines.) But the US government did not admit vaccines cause autism - they conceded one case that is highly complex and not necessarily representative of any other case and cannot be reasonably used to support the vaccine/autism connection.

David Kirby, author of Evidence of Harm, wrote a highly misleading article the other day in the Huffington Post on this issue. Orac has already done an excellent job of tearing down Kirby’s claims. He points out that legal cases are often decided for legal - not necessarily scientific - reasons. That the government only conceded that “compensation is appropriate.” That is all - they conceded nothing about the larger question of vaccines and autism. Orac also points out that if this case were a concession of a connection why would the petitioner’s lawyers settle and give away a case that could win them all their other cases?

David Kirby has also written a follow up article, where he publishes verbatim the US government’s decision. Kirby asks his readers:

If you feel this document suggests that some kind of link may be possible, you might consider forwarding it to your elected representatives for further investigation.

But, of course, if you feel that this document in no way implicates vaccines, then let’s just keep going about our business as usual and not pay any attention to all those sick kids behind the curtain.

I think Kirby is hoping that most people will not have the patience or medical background to read and understand the entire document, and that they will come away with a vague notion that there must be something to all this vaccine fear-mongering. What does the document really tell us?

To summarize the case history, the child in the case appeared normal and healthy, except for chronic otitis media, until about 20 months of age at which time he had a series of vaccines according to the routine vaccination schedule. Two days later the child had a fever to 102.3, was lethargic, irritable, and would arch his back when he cried. The child then developed a rash. It was later determined that the child had: “encephalopathy progressed to persistent loss of previously acquired language, eye contact, and relatedness.” The child regressed and developed symptoms similar to those of autism spectrum disorder. However, the child does not have autism - he has a regressive neurological disorder that includes blood and muscle abnormalities not seen in autism, and any clinical resemblance to autism is not a reflection of a common cause.

Six years after symptoms began the child also developed partial temporal lobe epilepsy that required treatment.

During this time the child also had an extensive workup, which discovered:

A CSF organic acids test, on January 8, 2002, displayed an increased lactate to pyruvate ratio of 28,1 which can be seen in disorders of mitochondrial oxidative phosphorylation.

A muscle biopsy test for oxidative phosphorylation disease revealed abnormal results for Type One and Three.

In February 2004, a mitochondrial DNA (”mtDNA”) point mutation analysis revealed a single nucleotide change in the 16S ribosomal RNA gene (T2387C)

It if often difficult or impossible to draw firm conclusions from a single case, so I will lay out what I see as all the possible alternative hypotheses to explain this information.

1) One possibility is that the child was perfectly normal prior to the vaccines, which caused an encephalitis (inflammation of the brain) which caused brain damage, including the later seizures. The metabolic disorder and mutation may be a red herring and have no bearing on the child’s clinical condition.

2) The mitochondrial disorder predisposed the child to have a reaction from the vaccines, resulting in encephalitis. The subsequent neurological regression was due to some combination of the vaccine-induced encephalitis and the underlying mitochondrial disorder.

3) The child’s mitochondrial mutation is the primary cause of their neurological regression, but that this regression was exacerbated by the vaccine-induced encephalitis (this seems to be the US government’s conclusion).

4) The child has a mitochondrial encephalopathy which is the sole cause of all of the child’s neurological signs and symptoms. The reaction to the vaccines may have played no role at all in the subsequent regression, and the child’s current neurological condition is exactly what it would have been had they never been vaccinated. It is even possible that the encephalitis was merely the first manifestation of the mitochondrial disorder and the timing after the vaccines was merely coincidental.

That lays out the spectrum of possibilities in this case. At this point in time we do not have (or at least I am not privy to) sufficient scientific information to say definitively where along this spectrum the truth lies. The US government’s decision was based partly on this uncertainty - erring on the side of compensating the child and family.

But we can discuss the plausibility of each scenario. Kirby dismisses anything resembling option 4, but his dismissal is naive and unjustified. In fact the patient’s clinical syndrome resembles what is called a mitochondrial encephalopathy - with increased lactic acid, abnormal muscle biopsy, neurological regression, appropriate age of onset, even seizures. It is probably not a coincidence that the child has a point mutation in a gene that has been previously linked to these very mitochondrial disorders. Kirby incorrectly argues:

While it’s true that some inherited forms of Mt disease can manifest as developmental delays, (and even ASD in the form of Rhett Syndrome) these forms are linked to identified genetic mutations, of which T2387C is not involved. In fact little, if anything, is known about the function of this particular gene.

This is misleading. Kirby refers to “this particular gene” which makes me think that he believes T2387C is a gene. It’s not - it describes a point mutation (at location 2387 a thymidine has replaced a cytosine). The gene is the 16S ribosomal RNA gene. Mutations in this gene have been identified to cause mitochondrial encephalopathy. So Kirby is just wrong. It is true that I could not find that this specific mutation has been identified before, but that is common in genetics - a disease is linked to point mutations in a specific gene (or perhaps specific regions of a gene) but most or all families identified have their own specific mutation.

This makes option 4 very plausible - it would be an incredible coincidence if this child just happened to have a mutation in a gene that was known to cause their exact constellation of neurological signs and symptoms and yet the mutation was not the sole or primary cause of those symptoms.

But it does not rule out option 3 - that the mitochondrial disorder was the primary cause of the child’s neurological disorder but that a reaction to the vaccines worsened the ultimate symptoms. Therefore the government’s decision was reasonable - but is absolutely not a concession about any claim made by the petitioners concerning a link between vaccines an autism.

It does, however, make any hypothesis resembling option 1 or 2 extremely unlikely. Further testing regarding the physiological effects of this child’s specific mutation would be helpful, and such testing may be under way but I could find nothing published to date. It is theoretically possible that the identified mutation does not cause a change in the gene product or mitochondrial function, and is therefore just a coincidence. But this is unlikely given the clinical features in this case are a good match to known mutations of that gene.

Kirby, however, apparently wants to wring as much fear and confusion out of these events as he possibly can. So now he speculates wildly that maybe children diagnosed with autism really have this mitochondrial disorder combined with vaccines (he has to keep vaccines in the loop). Given the rarity of such mutations, and the fact that there were specific features in this case that would likely be uncovered in the routine evaluation of a child with autism (like an elevated lactic acid), it is highly unlikely that there are many children with vaccine-triggered mitochondrial encephalopathy mimicking autism out there.

It has been found that some children with autism have mitochondrial dysfunction - one study found that 7.2% of subjects with autism had “definite mitochondrial respiratory chain disorder.” Poling et al, in response to this child’s case, did a retrospective study of children with autism and with other neurological disorders and found that “Aspartate aminotransferase was elevated in 38% of patients with autism compared with 15% of controls.” Such findings are preliminary - the only conclusions that can be drawn is that the association between autism and metabolic disorders requires further investigation. However, these studies did not look at the incidence of suspicious mitochondial mutations in autism, and these findings may not be relevant to this case.

Kirby also wildly speculates that perhaps the evil toxins in vaccines caused the mutation in the first place. He writes:

Use of the AIDS drug AZT, for example, can cause Mt disorders by deleting large segments of mitochondrial DNA. If that is the case, might other exposures to drugs or toxins (i.e., thimerosal, mercury in fish, air pollution, pesticides, live viruses) also cause sporadic Mt disease in certain subsets of children, through similar genotoxic mechanisms?

Among stiff competition, this is perhaps the most absurd and scientifically ignorant thing Kirby has every written. AZT does NOT cause a genetic disorder. AZT blocks DNA replication (it blocks the copying of DNA) - that is its mechanism as an anti-retroviral drug. In patients it can also block mitochondrial DNA replication, thereby causing mitochondrial depletion. This results in there being too few mitochondria (the energy factories of cells) in some cell populations and causes dysfunction in tissue that is especially susceptible to the effects of this dearth of mitochondria. This is a side effect of AZT and also other retrovirals because of sustained use at doses designed to inhibit DNA replication. This does result in some effects that are similar to mitochondrial genetic disorders - because both result in insufficient mitochondrial activity. But that is the only similarity. AZT does not cause a disseminated somatic mutation, which is the incredible analogy that Kirby is making.

What Kirby is suggesting is that in infants and toddlers toxins can cause the same point mutation in millions of different cells throughout the body. Toxin-induced mutations do not cause genetic diseases, unless they occur in a germ cell in which case a mother or father can pass the mutation onto their children. If it occurs in the womb then large cell populations may be affected (whatever cells derive from the cell that had the mutation). But in a child a point mutation would affect only one cell and any cells that derive from it. A toxic mutagen would cause different random point mutations in different cells. This could not cause the mitrochondrial encephalopathy in this child. It can increase the risk of cancer, because cancer can develop from a single mutation in a single cell that causes it to become neoplastic.

Conclusion

This is a unique and idiosyncratic case that raises more questions than it answers. In my opinion as a neurologist, with the information provided, the child has a mitochondrial encephalopathy. The role of the vaccines is unclear, but at worst a rare vaccine reaction exacerbated the underlying mitochondrial disorder. This case has no clear implication for the larger question concerning vaccines and autism, which is likely why both sides agreed to settle.

Yet those who insist, despite the evidence, on claiming that vaccines or mercury are linked to autism are likely to add this permanently to their litany of misinformation and fear-mongering.

Note: I am searching for any follow up information pertinent to this case and will post any addendum here.

DR. JON POLING TO DR. STEVEN NOVELLA ON AGE OF AUTISM

PolingsBy Dr. Jon Poling, father of Hannah Poling.

OPEN LETTER TO DR. STEVEN NOVELLA
IN RESPONSE TO "Has the Government Conceded Vaccines Cause Autism?"

Dr. Novella,

Thank you for generating interesting discussion regarding my little girl, Hannah Poling. I would like to give you additional information in order to generate further productive discussions on this matter amongst the neurology community. This information should assist you, Dr. DiMauro, and Dr. Trevethan, who have also commented publicly, to formulate better theories as to the significance of Hannah’s mitochondrial dysfunction in relation to her autism.

1. Mito Dysfunction or Mito Disease? Chicken or Egg?

To begin with, I would like to point out that the spectrum of mitochondrial dysfunction is probably considered more broad and complex than the spectrum of neurobehavioral abnormalities seen with autism. Dysfunction of the mitochondria, specifically dysfunction of the oxidative phosphorylation pathway, most likely contributes, but may not be the cause of many diseases—including Parkinson’s disease, Friedreich’s Ataxia, Alzheimer disease, etc. Thus, it is probably incorrect to refer to mitochondrial dysfunctional and mitochondrial disease interchangeably. Indeed, the role of the dysfunctional mitochondrial are yet to be clarified in these diseases. Thus, I will refer to Hannah’s metabolic condition as a mitochondrial dysfunction, not a mitochondrial disease.

2. Mito Genetic Finding? Mito mtDNA ‘red herring’ ?

ADDITIONAL GENETIC TESTING NOT AVAILABLE IN THE J CHILD NEUROL CASE REPORT: Dr. Shoffner performed genetic testing on both Hannah’s muscle and her mother’s leukocytes subsequent to our case report. Hannah (muscle mtDNA) and her mother (leukocyte mtDNA) were both found to be HOMOPLASMIC for the mtDNA T2387C transition mutation.
Our analysis of this genetic finding in the mtDNA was significantly different than those of other physicians that I’ve seen in scientific blogs or commentary. I suspect it would have been fatal to both Hannah and her mother if this homoplasmic mutation was pathogenic since (as I am sure you are aware) the mutation is on the 16S ribosomal subunit which is highly conserved. Thus, this mutation probably represents a benign polymorphism rather than pathogenic mutation. It is unlikely, but possible, that the mutation is significant to Hannah, but in such a case, it must work in concert with other nuclear genes to cause her mitochondrial dysfunction. To our knowledge, this point mutation has not been reported in cases similar to Hannah’s.

3. Encephalitis? Metabolic Encephalopathy? Or “Regressive Encephalopathy with Features of Autism Spectrum Disorder”

The other interesting term you used was encephalitis rather than encephalopathy. We are not sure that she had an “-itis” but we did clearly document a regressive encephalopathy based on not only our parental reporting, but also based on the pediatrician’s documents, affidavits from other family members, and the growth curve measurements (injury pattern). Early on in the regression we did note back arching (opisthotonus), fever, and disrupted sleep. Although fever occurred a lumbar puncture was not performed.

An interesting developing story in autism research is the immune/inflammatory connection. In her senior resident thesis, Dr. Anne Comi, a former JHU colleague, along with Dr. Andy Zimmerman, reported, the increased prevalence of autoimmune disease in families of autistic offspring. Interesting, Hannah also has a maternal family history of autoimmune disease. Dr. Carlos Pardo, another one of my former chief residents, along with Andy and Dr. Vargas, published a beautiful study in the Archives of Neurology, demonstrating neuroinflammation on autopsy of brain samples and inflammation cytokine markers in the CSF of individuals with Autism. The interesting thing was that inflammation was demonstrated in autopsy specimens from adults as old as 44 years of age. The conclusion was that further research would be required to determine if inflammation was a primary disorder in autism or; alternatively, if inflammation and microglial activation was secondary to neurodegeneration. Dr. Sudhir Gupta at UC Irvine has a nice model of how the two pathways of neuroinflammation and mito dysfunction may not be mutually exclusive. This remains to be seen; however, study of mitochondrial dysfunction and neuroinflammation hold the promise of treatment development. The two avenues of research deserve funding at the highest levels.

4. How many Hannah Polings are out there?

The short answer is that nobody knows. However, there is emerging data to suggest that she is not alone.

Dr. Shoffner will be presenting his experience with 37 patients with combined autism and mitochondrial dysfunction at the AAN meeting in Chicago this April. 65% of his referrals are positive for mitochondrial dysfunction. Of course, his yield is subject to referral bias as a mito expert, so the prevalence of mitochondrial dysfunction in Autism is surely less than 65%.

The best estimate to date of the prevalence of mitochondrial dysfunction in autistic patients comes from Oliviera et al. in a population of 120, 5 of 69 (or 7.2%) showed mitochondrial dysfunction. If this is generalized to the US estimate of 1 million patients with ASDs, then the number of kids like Hannah could be 72,000! Isn’t this worth further study?

Dr. Shoffner furthermore advocates, along with us, that vaccination is important even for kids with mitochondrial dysfunction. I would argue that you should not give nine at one time and that none of them should contain Thimerosal (mercury).

5. Thimerosal—On or Off the Table?

I don’t want to dwell on mercury, as this theory is not why HHS conceded Hannah’s case (imo). Dr. DiContanzo just wrote an interesting blog about how his opinion of mercury in vaccines has changed (http://drugs.about.com/b/2008/03/08/mercury-in-vaccines-and-autism-the-burden-of-proof-may-shift.htm).

My opinion is that mercury is a potent neurotoxin. Therefore, don’t inject it into kids! Interestingly, basic research studies have shown that Thimerosal toxicity occurs through mitochondrial pathways. Officials point to the large epidemiology studies as proof that there is no link between thimerosal and autism. However, these studies are not powered to disprove the null hypothesis when considering that the mitochondrial autistic population may be just a small percent of the case totals. Remember that while the CDC sponsored Verstraten study is hyped as a negative study, it DID find a statistically significant increase in childhood tics in those exposed to higher doses of thimerosal.

6. Hannah was destined to regress? Or was she?

Some experts have already stated that ‘mitochondrial disease’ is degenerative so the vaccine reaction was just the start of an inevitable decline. This was neither the opinion of Dr. Richard Kelley at KKI nor Dr. John Shoffner. In fact, the markers that led us down the mitochondrial trail (inc AST but not ALT, low serum bicarbonate, and slight increased CK, increase in the alanine to lysine ratio on PAA) are no longer present. Furthermore, in our pilot study (unpublished but mentioned in the J child neurol paper), Dr. Frye (the statistician for our study and also a child neurologist) found a non-significant trend that AST decreased toward normal with increasing age. With further studies we hoped to examine the hypothesis that this abnormality may be representative of a developing/immature biochemical pathway present in some children.

7. Triple Hit Hypothesis—#1Underlying genetic susceptibility #2Insult must occur during specific developmental period #3 A certain vaccination or combination thereof is the environmental trigger (?vaccine component like thimerosal ?direct immune stim/fever reaction ?live virus reaction?)

The implication is that Hannah’s type of autism requires a genetic susceptibility and properly timed insult to manifest disease. We have not subjected Hannah to another muscle biopsy or re-examined ox phos functional assays that were published in the paper. I can inform your readers though that the serum biochemical markers have resolved, growth resumed and continues along a normal trajectory, and there have been no other episodes of regression since 2000. We are however left with autism and later in 2006, epilepsy.
It is recommended that studies be initiated immediately to screen siblings of cases to identify biochemical markers so as to identify potential screening tests.

I agree with the mainstream that my daughter’s case has raised many intelligent discussions and questions. I’m very proud of her for starting this discussion. Our hope is that further research into this case and others like it, we will be also to find screening tests to prevent what happened to my daughter from happening to anybody else.

(Dr. Poling acknowledges the editorial comments and insightful suggestions of Dr. Richard E. Frye. He also would like to declare his conflicts of interest. First of all, he is the father of Hannah Poling. Dr. Poling has also accepted consultancy or speakers honoraria from Pfizer, Eisai, Ortho-McNeil, Biogen, Teva, Immunex (now Amgen), and Allergan.)

PS While I thought it useful to clarify some of the neurological issues raised by the government's concession of my daughter's case, please understand that I will not be able to respond to individual comments posted. Thank-you. Jon

Phil and Misty Hiatt: "We Were Compensated Too!"

I have calmed down from the appoplexia that overtook me when learning that Hanna was not the first autistic child to be paid from the Vaccine Injury Compensation Fund, but at least the tenth, to write about this somewhat coherently.

Since then David Kirby, The Pensacola News Journal, The Schafer Autism Report and the Age of Autism's Dan Olmsted have joined CBS in reporting that there are more families out there who want to go public with their settlement stories.

As you may recall, in reporting on Hannah's story on March 6th, Sharyl Attkisson on The CBS Evening News reported that:

"While the Poling case is the first of its kind to become public, a CBS News investigation uncovered at least nine other cases as far back as 1990, where records show the court ordered the government compensated families whose children developed autism or autistic-like symptoms in children including toddlers who had been called "very smart" and "impressed" doctors with their "intelligence and curiosity" … until their vaccinations.

They were children just like Hannah Poling."

CBS News was apparently a few steps behind David Kirby, who on March 3rd posted on an autism list:

"And next week, I just might drop another bombshell – A BIG one, from another case in VICP.

Turns out that people who settled with the government now want their cases to be known as well. They are seeking me out. You would be AMAZED at what the government has secretly admitted.

It contradicts many things that the Feds, AAP, and SWORN government witnesses have been saying publicly, under oath no less -- at least on this one particular vaccine injury related issue.

I love the smell of perjury charges in the morning.

Stay tuned

Cheers"

CBS was a day ahead of the Pensacola News Journal that wrote about the Hiatt family that got a judgment in 2002:

In 1999, Misty and Phil Hiatt of Pensacola, parents of 10-year-old triplets, were among the first to assert a link between childhood vaccines and autism-like symptoms.

Misty Hiatt said she and her husband, a professional baseball player for 16 years, saw their babies' lives change dramatically after they received routine immunizations at 14 months.

She said daughter Madison began suffering from severe autism-like symptoms. Daughters Morgan and Mackenzie also were affected, though less severely.

In 2002, the Hiatts received a settlement from the National Vaccine Injuries Compensation Program, a fund Congress set up to pay children injured by vaccines and to protect makers from damages as a way to help ensure an adequate vaccine supply. Since the fund started in 1988, it has paid about 950 claims — none for autism but some for autism-like symptoms.

"The government settled with our family and accepted responsibility for the injury the vaccines caused my daughter, Madison," Misty Hiatt said.

I have already discussed the difference between "autism" and "autism-like" symptoms. There is none.

And today the Schafer Autism Report ran a letter they got from the Hiatts saying that when they got their settlement, they had the impression that many other families like theirs had been compensated:

"We Were Compensated, too.

We were also compensated by the Federal Government in 2002. Our child suffered the same diagnosis after her routine immunizations. Encephalopathy with autistic like symptoms. I am not sure why people think this is the first case? Maybe they are just the first to go so public. I wonder how many other families have been compensated for the exact same symptoms? When we settled with the government I did not get the impression that we were that unique; quite the opposite as I spoke to the Special Master (the judge for the compensation program). - Misty Hiatt"

Finally, today Dan Olmsted brings to our attention a passage from an AP story in which Gary Golkiewicz, Chief Special Master for the U.S. Court of Federal Claims who oversees the vaccine court, tells us himself that Hannah's case is not the singular exception that we have been led to believe it is:

'Years ago, actually, I had a case, before we understood or knew the implications of autism, that the vaccine injured the child's brain caused an encephalopathy,' he said. And the symptoms that come with that 'all [fall?] within the broad rubric of autism.'

And there are other somewhat similar cases, Golkiewicz says, that were decided before autism and its symptoms were more clearly defined."

Two thoughts on that: We've known the symptoms of autism since exactly 1943. And since the vaccine court is known to be gruesomely stingy, it's quite some admission to say there were other, earlier cases. Maybe some of our befuddled colleagues in the mainstream media ought to find out more about those cases that, according to the top judge, resulted in brain injury and fall "within the broad rubric of autism."

And yet in the face of all this, Julie Gerberding, the head of the CDC said this about the Hannah Poling case setting a precedent for other cases of vaccine induced autism:

"This is a complete mischaracterization of the findings of a very simple situation of one child with an unusual disorder, and it would be completely wrong to say that this has bearing to the vast majority of children with autism,"

Julie Gerberding is telling us that Hannah is a rare exception. We now know that she is not.

Autism parents are going to spend tomorrow calling the White House asking for her resignation.

Either Julie knew about these previous rulings, in which case she is lying to us and should be removed from her post, or she did not know about these previous rulings, in which case she is incompetent and should be removed from her post.

What this means is that for almost 20 years the government has had the evidence that vaccines cause autism and they have buried it and lied to the public. For two decades doctors have been denied the information they needed to make responsible health decisions for their patients. The parent of every child vaccinated since 1990 has been denied "informed consent" in their decision making process on if and how to vaccinate their children. How many hundreds of millions of children is that? Or billions?

What this means to my family is that a full year after paying the Hiatts for their daughter's vaccine induced autism, they were telling me that it was safe to vaccinate Chandler with out fear of having his shots trigger autism, resulting in my son's vaccine induced “Autism-like symptoms”.

In light of all this, I am calling for congressional hearings to find out what the government knew and when they knew it.

I am calling for full disclosure on the part of the Vaccine Injury Compensation Program to release every case of a child who was paid for their "Autism-like" vaccine injury so we can get to the bottom of the vaccine/autism connection. Because those cases hold vital clues to what has happened to my son, and what treatments might heal him.

If the families involved do not want their details released, the cases can be presented in such a way as to protect their privacy. But if what David Kirby is reporting, that families are coming to him to make their cases known, such privacy measures may not be needed.

I am looking forward to seeing what new information David Kirby and any other journalist that has begun to wake up to this miscarriage of justice can bring us about these other cases.

... and if this pans out the way it looks like it is going to... Kirby is right... some people need to go to jail.

Its Not Just The Mercury: Aluminum Hydroxide In Vaccines

When parents began suspecting that their children's autism was triggered by their vaccines, and those parents in the scientific professions began to look at the plausibility of the vaccine/autism connection, one ingredient jumped out at them as the most likely culprit. Mercury. Excessive mercury. So much mercury in one typical shot (25mg)that according to EPA guidelines a person must weigh 550lbs to safely process the amount of mercury that was being injected into a child. And they often got more than one shot at a time.

After all mercury is the most toxic substance on earth that does not set off a geiger counter.

It has taken more than a decade, but the public and scientific community is finally on the same page on the idea that it does not belong in vaccines. And yet is it still in vaccines. We continue to work on the problem.

But now that the mercury message is out there, it is time for the scientific community to begin to turn their attention to the other three well known dangers that are in vaccines. Aluminum, Monosodium Glutamate, and Formaldehyde.

Today we are going to give Aluminum a look.

Aluminum is known to be associated with degenerative, fatal neurological conditions like Parkinson's, ALS (Lou Gehrig's) and Alzheimer's. And yet according to the CDC, it is in the following vaccines:

Anthrax, DTaP (all brands), DT (all brands), Hib/Hep B (Comvax), Hep A (all brands), Hep B (all brands), HPV (Gardasil), Pneumococcal (Prevnar), Rabies (Biorab), Td (all brands), and Tdap (all brands).

That is most of the vaccines on the CDC's list.

The reason that aluminum is in our vaccines is because it is an adjuvant.

Generally speaking, the way vaccines work is that they contain a virus and substances called ‘adjuvants’ (like mercury and aluminum) that kick the immune system into high gear so that they go on the hunt for the viruses, eat ‘um up, and create antibodies against further infection.

In people with typical immune systems, the body then stands down from high alert. But in some people, it doesn’t, and the immune system begins to behave like early 20th century Germany and attacks what ever is in sight. The result, autoimmune disorders.

A few examples of autoimmune disorders: When the immune system attacks the connective tissue, you get arthritis, when it attacks the mylon sheath around the nerves, you get Guillain-Barré Syndrome (a known side effect of the flu shot that causes paralysis), and when it attacks the pancreas you have Type 1 Diabetes. And on and on.

Because autism was first seen as a psychiatric problem caused by bad parenting, it has taken decades for it to be properly medically investigated, and for the autoimmune features of the disorder (i.e. cytokines in the brain causing swelling leading to cognitive dysfunction) to be recognized. (Which is why even mild anti inflammatory agents like fish oil improve communication skills of so many people with autism, and why parents report that children’s autistic symptoms seem to improve when their kids are sick.)

(When Chandler was diagnosed and we had his immune system tested, viola… hyper drive. I just thought he had rough skin… turns out it was mild eczema. When I started him on fish oil and his rough skin turned back into baby skin and his eye contact and verbal skills improved.)

So the reason that aluminum needs as hard a look as a vaccine component as mercury does, is because we are learning that it also causes cell death. A lot of cell death. In the brain.

Canadian neuroscientist Chris Shaw did not set out to shake confidence in vaccination, but what he and his team found when testing Aluminum Hydroxide, the form used most often in vaccines, really upset them.

"No one in my lab wants to get vaccinated," he said. "This totally creeped us out. We weren't out there to poke holes in vaccines. But all of a sudden, oh my God-we've got neuron death!"

Vaccines Show Sinister Side
By Pieta Woolley
Straight.com
March 23, 2006

If two dozen once-jittery mice at UBC are telling the truth postmortem, the world's governments may soon be facing one hell of a lawsuit. New, so-far-unpublished research led by Vancouver neuroscientist Chris Shaw shows a link between the aluminum hydroxide used in vaccines, and symptoms associated with Parkinson's, amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and Alzheimer's.

Shaw is most surprised that the research for his paper hadn't been done before. For 80 years, doctors have injected patients with aluminum hydroxide, he said, an adjuvant that stimulates immune response.

"This is suspicious," he told the Georgia Straight in a phone interview from his lab near Heather Street and West 12th Avenue. "Either this [link] is known by industry and it was never made public, or industry was never made to do these studies by Health Canada. I'm not sure which is scarier."

Similar adjuvants are used in the following vaccines, according to Shaw's paper: hepatitis A and B, and the Pentacel cocktail, which vaccinates against diphtheria, pertussis, tetanus, polio, and a type of meningitis.

To test the link theory, Shaw and his four-scientist team from UBC and Louisiana State University injected mice with the anthrax vaccine developed for the first Gulf War. Because Gulf War Syndrome looks a lot like ALS, Shaw explained, the neuroscientists had a chance to isolate a possible cause. All deployed troops were vaccinated with an aluminum hydroxide compound. Vaccinated troops who were not deployed to the Gulf developed similar symptoms at a similar rate, according to Shaw.

After 20 weeks studying the mice, the team found statistically significant increases in anxiety (38 percent); memory deficits (41 times the errors as in the sample group); and an allergic skin reaction (20 percent). Tissue samples after the mice were "sacrificed" showed neurological cells were dying. Inside the mice's brains, in a part that controls movement, 35 percent of the cells were destroying themselves.

"No one in my lab wants to get vaccinated," he said. "This totally creeped us out. We weren't out there to poke holes in vaccines. But all of a sudden, oh my God-we've got neuron death!"

At the end of the paper, Shaw warns that "whether the risk of protection from a dreaded disease outweighs the risk of toxicity is a question that demands our urgent attention."

He's not the only one considering that.

The charge that there's a sinister side to magic bullets isn't new. With his pen blazing, celebrity journalist Robert F. Kennedy Jr. popularized vaccine scepticism with his article arguing that mercury in vaccines causes autism, which ran in the June 2005 Rolling Stone and on-line at Salon.com. So did last year's vaccines-linked-to- autism bestseller, Evidence of Harm by David Kirby (St. Martin's Press). But there's a potential public-health cost to all the controversy, according to the B.C. Centre for Disease Control.

"Vaccines have been a victim of their own success," spokesperson Ian Roe told the Straight in a telephone interview from Ottawa. Diseases such as polio, which killed his father-in-law, are almost eradicated and therefore no longer serve as a warning to parents. But the epidemic threat is still real. "If everyone decided to not get vaccinated, we'd live in a very different world."

Canada's last national immunization conference, in December 2004, heard a report that vaccine coverage is sometimes low. For diphtheria, the Public Health Agency of Canada found that just 75 percent of two-year-olds are immunized; the target is 99 percent. For tetanus, just 66 percent of 17-year-olds are immunized, compared to a target of 97 percent.

Dr. Ronald Gold, the former head of the infectious-disease division at Toronto's Hospital for Sick Children, told the conference that "we will never be without an anti-vaccine movement," but "in reality, there is no scientific evidence for these myths."

Can I just stop here for a second and point out that in the middle of offering you scientific evidence for the theory that vaccines cause serious and permanent brain damage that I AGAIN have to be faced with someone in medical authority saying, "NO LINK"! How many studies have to find a link before they will stop saying it, "no link"?

There are hundreds of studies, but they don't want to look at them.

I will start writing more about them.

The collective denial is staggering.

Shaw acknowledges that there's a lot of pressure on parents to vaccinate their children. "You're considered to be a really bad parent if you don't vaccinate," he said-and your child can't attend public school. "But I don't think the safety of vaccines is demarcated. How does a parent make a decision based on what's available? You can't make an intelligent decision."

Conservatively, he said, if one percent of vaccinated humans develop ALS from vaccine adjuvants, it would still constitute a health emergency.

It's possible, he said, that there are 10,000 studies that show aluminum hydroxide is safe for injections. But he hasn't been able to find any that look beyond the first few weeks of injection. If anyone has a study that shows something different, he said, please "put it on the table. That's how you do science."

Neuroscience research is difficult, Shaw said, because symptoms can take years to manifest, so it's hard to prove what caused the symptoms.

"To me, that calls for better testing, not blind faith."

He pointed out that George W. Bush passed legislation that opens the door for the USA to order a nationwide anthrax immunization campaign, with the threat of bioterrorism.

Shaw's paper is currently undergoing a peer review.

Despite the fact that Shaw announced his study in March of 2006, only three months ago, Melinda Wharton, Deputy Director of the National Center of Immunization and Respiratory Diseases at CDC, gave an interview to Jaye Watson of WXIA TV in Atlanta and here is what she said about the dangers of aluminum content:

Q. Aluminum is used in vaccines. This is a question I bring with me from attending the conference and seeing a panel of 3 doctors or so talk about aluminum and the amount in vaccines. One said that the aluminum exposures for the vaccine’s recommended of the 2 month visit exceed the suggested safety limits set by the FDA. Has the CDC tested the toxicity of aluminum in vaccines?

A. The vaccines are licensed by the FDA, and the vaccines meet FDA standards, so no, CDC hasn’t looked at that particular issue, but that is handled by the Food and Drug Administration’s part of vaccine licensing.

Q. So, that would almost be counter productive….

A. It wouldn’t be licensed if it was toxic.

Because we all know that the FDA would never license something that was harmful to people. (Thalidomide is currently an FDA approved drug? What the hell?!)

Shaw's study completed peer review, it was published in in 2207 in Neuromolecular Medicine:

Aluminum adjuvant linked to gulf war illness induces motor neuron death in mice.
Neuromolecular Med. 2007;9(1):83-100.
Petrik MS, Wong MC, Tabata RC, Garry RF, Shaw CA.

Department of Ophthalmology and Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada.

Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological disorders. Whereas many environmental factors have been linked to GWI, the role of the anthrax vaccine has come under increasing scrutiny. Among the vaccine's potentially toxic components are the adjuvants aluminum hydroxide and squalene. To examine whether these compounds might contribute to neuronal deficits associated with GWI, an animal model for examining the potential neurological impact of aluminum hydroxide, squalene, or aluminum hydroxide combined with squalene was developed. Young, male colony CD-1 mice were injected with the adjuvants at doses equivalent to those given to US military service personnel. All mice were subjected to a battery of motor and cognitive-behavioral tests over a 6-mo period postinjections. Following sacrifice, central nervous system tissues were examined using immunohistochemistry for evidence of inflammation and cell death. Behavioral testing showed motor deficits in the aluminum treatment group that expressed as a progressive decrease in strength measured by the wire-mesh hang test (final deficit at 24 wk; about 50%). Significant cognitive deficits in water-maze learning were observed in the combined aluminum and squalene group (4.3 errors per trial) compared with the controls (0.2 errors per trial) after 20 wk. Apoptotic neurons were identified in aluminum-injected animals that showed significantly increased activated caspase-3 labeling in lumbar spinal cord (255%) and primary motor cortex (192%) compared with the controls. Aluminum-treated groups also showed significant motor neuron loss (35%) and increased numbers of astrocytes (350%) in the lumbar spinal cord. The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly an additional role for the combination of adjuvants.

(One note on what Apoptosis is. It is basically when a cell self destructs.

Apoptosis is also the process that is taking place, via mitochondrial dysfunction, when Thimerosal is administered, that came to our attention when Dr. Jon Poling discussed the details of his daughter Hannah's case.

Hanna was the first case of an autistic child paid from the US Vaccine Injury Compensation Fund to be made public, although details are coming to light that she is at least the 10th such child. The other families are currently working to make their cases known.)

So here is the questions that parents are currently beginning to ask: as thimerosal has been in the process of removal from vaccines, have manufacturers replaced it with higher doses of aluminum to added to make up for the adjuvant properties lost when mercury was no longer present? How do we know what a safe level of aluminum is for our children? Does the CDC even care?

CBS: Sharyl Attkisson speaks to Rep. Dave Weldon About the Poling Case

The Polings on Good Morning America

Diedre Imus On Autism On Imus

From this morning's Imus:

MUS: Welcome to Diedre Imus

DIEDRE: Good morning to everyone.

IMUS; I saw you on CNN yesterday. They were watching you over at the radio station as they were getting ready for a big luncheon, talking about the vaccine case. Explain to me, first of all, what's that all about?

DIEDRE: Well, the Poling family's daughter, Hannah.....the government conceded in vaccine court, that the vaccines did cause, in their words "Autism-like symptoms"...and.....as I made clear yesterday on CNN, (with Hiede Collins, whose great by the way), that there is no valid distinction between "autism-like symptoms and autism". It's autism. Their child has autism. It was probably one of the best days so far, for all these families who have a child with autism...because this raises a lot of awareness and a lot more questions that parents have been asking and haven't been getting answers to. What do we do about vaccines? Hiede even asked me that. I talked about the mercury and other toxins in the shots. But, there's a couple of things parents need to do. They have to ask their pediatricians and ask the CDC to look at the schedule. Many, many organizations are recommending this. The vaccines must be mercury and toxin free...because they do contain aluminum, formaldehyde and some other toxins. Aluminum is a neuro-toxin, formaldehyde is a known carcinogen, on top of the mercury that's in them. Also, fewer shots. When I was a kid and even in 1983, there were only 10 shots given before you were 5 years old. Today, these children, along with Hannah, are given up to 36 vaccines. Hannah was given 9 vaccines in 1 day. There's a lot of pressure for pediatricians to get them in the office and give them their shots. They do it out of convenience. I have your child, lets give them the shots. Even Ms. Poling, a registered nurse, said in the press conference she went in for her 18 month checkup and she had skipped some shots, so they gave her those shots as well.

IMUS; You're not asking, I know you're not because we had Wyatt vaccinated, we just had him vaccinated with thimerosal free vaccines. So, you're not saying parents shouldn't get their kid vaccinated?

DIEDRE: No, that's not what I'm saying and that's not what any parent out there is saying. What they are saying is the vaccine schedule needs to change. Even Dr. Sanja Guptka said it last night. That we're at a point here where we maybe need to look at the schedule because there are so many vaccines that we're giving to children. They are getting so many and a lot are susceptible and it's ruining their immune systems. So, fewer shots, given later in life and also spacing them out. In fact, we did that with Wyatt. I don't go in the doctor's office and he gets 3 or 4 or 5 shots. I would ask they be separated. You come back in another month, so you can space them out. So as the child is developing, it's not so much of a burden. At the same time, they have to be given shots without all these toxins.

IMUS: Don't they bunch these shots together for the convenience of the doctors and in a lot of cases for the parents it's an economic situation., where they have to take off work to haul them to a doctor.

DIEDRE: Absolutely. Well that's why they do this. Convenience and money.

IMUS: It's not just for them, it's also for the parents in some cases. So what are parents to do?

DIEDRE: It's important now that this case is out. A lot of parents that didn't know this or weren't paying attention....or heard it and their doctor said "Don't worry". I think maybe they will, because Hannah Poling is only one out of many. Even last night, they were trying to say this might be an isolated case. Julie Gerberding from the CDC, their statement was unbelievable because they didn't address the issue. The danger of getting that many shots with all those toxins and covering up with a vaccine schedule that should be made safer for our children.

IMUS: What they never calculate, even I understand, when giving these multiple shots to children with thimerosal,......aren't most of the vaccines now, except for the flu vaccines, free of thimerosal?

DIEDRE: Well, they contain trace amounts. They call them thimerosal-free or preservative-free...what that means is there is still a trace amount in the manufacturing of vaccines...and they you put the needle into the child. They used to say 24 micrograms, which is the full amount in flu shots, or, 12 micrograms. They used to call that trace amounts. So we still have a dilemma there, because trace amounts.......NO AMOUNT OF MERCURY......has been proven to be safe. No doctor will tell you it's okay. We know the smallest amount of mercury can kill cells, can destroy animal brains. There are so many tests that have been done on this. When they took out most of the mercury, they replaced it with aluminum.

IMUS: As I started to say, what they failed to calculate back when thimerosal as routinely in these vacines....if you add 25 micrograms for each shot and you give a kid 5-6-8 shots...on the Poling kid 9 shots....and they all contained thimerosal, the CDC or IOM, or whoever is supposed to think about it, injecting that into the bloodstream of an infant child would be more than a 550 pound adult male could take.

DIEDRE: Excellent point. That point should be acknowledged because that is exactly what happened over the years when they accelerated the vaccine schedule.

IMUS: I saw the Gerbil, what's her name?

DIEDRE: Gerberding, she's head of the CDC.

IMUS: I saw Julie Gerbilding, saying this was an isolated case. As you just said a couple of minutes ago, there is no way you could conclude all of the other cases are the same. Aren't there a bunch of cases pending that are identical to the Poling's kid?

DIEDRE: Yes. There's 5,000 cases just like Hannah Poling pending. So its quite disturbing to have the head of the CDC make a comment like that. You would think she would address making the vaccines safer and pushing for research. She had that opportunity with everyone listening yesterday to say: "We really have to look into this to make sure because there is already enough of a connection" and all these other studies that have been done showing a link. But they keep denying. As you can see, this really exploded the issue.

IMUS" It reminds me of the tobacco situation.

DIEDRE: Oh my God. It's very similar, if not worse.

IMUS: Earlier in this conversation, what was the woman you were on CNN with?

DIEDRE: Hiedi Collins

IMUS: You said she was great?

DIEDRE: Well, she asked questions that a lot of people won't ask. She really wanted to know about the vaccines. This has been an issue, you've been asking for years, nobody else will ask. Finally you get people like Hiedi Collins and people at CNN now asking the same questions.

IMUS: Thanks for explaining the issue to us. I know it makes people crazy and they want to pull their hair out, but they wouldn't feel that way if they met one of these parents who has a child with autism.

CHAS MCCORD: It doesn't now, not nearly as much as it did. Because the Poling case is a wake-up call.